Enteric Glia: The Origin of Duodenal Gastrinomas?

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Enteric Glia: The Origin of Duodenal Gastrinomas? Brian D. Gulbransen Gastroenterology Volume 153, Issue 6, Pages 1473-1475 (December 2017) DOI: 10.1053/j.gastro.2017.10.029 Copyright © 2017 Terms and Conditions

Figure 1 Proposed glial mechanisms contributing to the development of MEN1-associated duodenal gastrinomas. Gastrin, derived from G cells, glia and other sources, acts on glial cholecystokinin B (CCKB) receptors to stimulate a protein kinase A (PKA)-dependent translocation of menin from the nucleus to the cytoplasm, where it is degraded by the proteasome. The decrease in menin releases the suppression of gastrin gene expression and triggers a feed-forward loop that contributes to hypergastrinemia. Gastroenterology 2017 153, 1473-1475DOI: (10.1053/j.gastro.2017.10.029) Copyright © 2017 Terms and Conditions