Juliana Saraiva Anjos, MD, Ludmila F. M. F

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Could Low-Protein Diet Modulate Nrf2 Pathway in Chronic Kidney Disease? Juliana Saraiva Anjos, MD, Ludmila F.M.F. Cardozo, PhD, Marta Esgalhado, MD, Bengt Lindholm, PhD, Peter Stenvinkel, PhD, Denis Fouque, PhD, Denise Mafra, PhD Journal of Renal Nutrition Volume 28, Issue 4, Pages 229-234 (July 2018) DOI: 10.1053/j.jrn.2017.11.005 Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Proposed mechanisms of action of LPD that may reduce NF-kB activation and increasing expression of Nrf2. CAT, catalase; GPx, glutathione peroxidase; GSTs, glutathione S-transferase; HO-1, heme oxygenase-1; IL, interleukin; IS, indoxyl sulfate; LPD, low protein diet; NADPH, nicotinamide adenine dinucleotide phosphate; NF-kB, nuclear factor Kappa B; NQO-1, quinone oxidoreductase 1; Nrf2, nuclear factor-erythroid 2-related factor 2; PCS, p-cresyl sulfate; ROS, reactive oxygen species; SOD, superoxide dismutase. Journal of Renal Nutrition 2018 28, 229-234DOI: (10.1053/j.jrn.2017.11.005) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions