Ability of biomarkers to predict small bowel inflammation in spondyloarthitis. Ability of biomarkers to predict small bowel inflammation in spondyloarthitis.

Slides:

Advertisements

Similar presentations

Biomarkers Managing IBD

Advertisements

Introduction Diabetic ulcers are the most common foot injury leads to lower extremity amputation in Diabetes Mellitus (DM) patients underwent lower-extremity.

C-Reactive Protein: New Applications Dr Job Ubbink, D.Sc (Pret), MRCPath (Lond) Consultant: Chemical Pathology.

Ghassan Wahbeh MD Associate Professor, Director IBD Program Seattle Children’s Hospital University of Washington.

A Sticky Situation A mouse model of diabetes-accelerated atherosclerosis exhibits elevated endothelial cell VCAM1, ICAM1 and CCL2 expression: Possible.

Mimics of IBD Sunanda Kane MD MSPH Mayo Clinic Rochester.

C Reactive Protein Coronary Heart Disease Genetics Collaboration BMJ 2011;342:d548.

Crohn’s Disease Daniel Ustinov Nathan Hann Dylan Innamorati PHM142 Fall 2015 Coordinator: Dr. Jeffrey Henderson Instructor: Dr. David Hampson.

Bone Morphogenetic Protein-7 Modulates Genes that Maintain the Vascular Smooth Muscle Cell Phenotype in Culture by Haimanti Dorai, and T Kuber Sampath.

NGUYEN VAN SI. MD. Supervisor: KYOTAKA KUGIYAMA. MD. PhD.

From: Diabetic Retinopathy: Battling the Global Epidemic

The Power of New Biomarkers to Detect Early Ischemia

Effect of Periodontal Therapy on GCF and Serum Levels of High-Sensitive C- reactive protein in Chronic Periodontitis Patients Alaa M Attia: Associate.

Baseline Characteristics of Women and Men in Whom Coronary Heart Disease Developed during Follow-up and Matched Controls - A Jennifer K. Pai et al. N.

Fig. 1. Pathological mechanisms of asthma

Lancet April 29; 389(10080): 1710–1718. doi:10

The Prognostic Value Of Dynamic Monitoring C-Reactive Protein (CRP) Serum Levels In NK/T-Cell Lymphoma by Bing Bai, Qi-chun Cai, Xiao-Xiao Wang, Qingqing.

Figure 3 Example of how a noncoding regulatory rheumatoid

Volume 145, Issue 2, Pages (August 2013)

The role of viruses in acute exacerbations of asthma

Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease Julián panés*, D.Neil Granger‡ Gastroenterology

Cross-reaction between Yersinia outer membrane proteins and anti-Borreli antibodies in sera of patients with Lyme disease E. Golkocheva-Markova, I. Christova,

Figure 4 Antinuclear antibodies and disease activity in SLE

Nat. Rev. Nephrol. doi: /nrneph

Change in secondary endpoints over time: (A) LS mean change from baseline in DAS28-CRP through Week 32, (B) mean change from baseline in CRP through Week.

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease

Association between n-3 polyunsaturated fatty acid content of red blood cells and inflammatory biomarkers in patients with peripheral artery disease

Microvascular responses to sepsis: clinical significance

Nat. Rev. Cardiol. doi: /nrcardio

Changes in PMR-AS, CRP levels, and GC dosage (prednisone) following TCZ therapy in 7 patients with PMR. Since our series included patients with long duration.

IL-18 Regulates Melanoma VLA-4 Integrin Activation through a Hierarchized Sequence of Inflammatory Factors María Valcárcel, Teresa Carrascal, Olatz Crende,

(A) Proposed new ANA result interpretation algorithm that includes the anti-DFS70 results. (A) Proposed new ANA result interpretation algorithm that includes.

Xenobiotic receptor meets NF-κB, a collision in the small bowel

Deposition of eosinophil-granule major basic protein and expression of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in the.

Figure 1: Serum LDH levels elevated significantly in KD and febrile non-KD patients. LDH levels were respectively measured in KD, compared with FC and.

Nat. Rev. Cardiol. doi: /nrcardio

Percentages of (A) ACR 20, 50, and 70 responders, and (B) patients with DAS28-CRP ≤ 3.2 or < 2.6 during 5 years. Percentages of (A) ACR 20, 50, and 70.

Nat. Rev. Nephrol. doi: /nrneph

Figure 3 Mendelian randomization (MR) using a genetic

Clinical and serological evolution of the presented case.

Elliott P, et al. JAMA 2009;302:37-48.

Inflammatory health effects of indoor and outdoor particulate matter

Clinical responses over time.

Psoriasis and Systemic Inflammatory Diseases: Potential Mechanistic Links between Skin Disease and Co-Morbid Conditions Batya B. Davidovici, Naveed Sattar,

The inflammatory response.

Hypothesised conceptual framework of the association between lung and vascular events. Hypothesised conceptual framework of the association between lung.

Endothelial expression of intercellular adhesion molecule 1 and vascular cell adhesion molecule 1 is suppressed by postbypass plasma containing increased.

Thrombosis and Inflammatory Bowel Disease

Odds ratios for achieving ACR50 response, ACR70 response, DAS28-CRP LDA, DAS28-CRP remission and CDAI LDA at weeks 12 and 24. High, >median value in overall.

Increased ICAM-1 expression in aortic disease

Fishing for Biomarkers with Antigen Mimics

Correction Journal of Vascular Surgery

Association of myeloperoxidase with total and cardiovascular mortality in individuals undergoing coronary angiography—The LURIC study Hubert Scharnagl,

Figure 1 New therapeutic approaches in IBD therapy based on blockade of T-cell homing and retention Figure 1 | New therapeutic approaches in IBD therapy.

(A, B) ... (A, B) The frequencies of Tregs from patients with SLE (n = 50) and healthy controls (n = 20) are shown. (C) Data plots show the correlation.

Mean differences with 95% CI between the Internal Family Systems (IFS) intervention group and the education group in study outcomes at baseline and 3,

Volume 115, Issue 4, Pages (October 1998)

Figure 2 Immune changes in peripheral blood of pregnant patients with NMO Immune changes in peripheral blood of pregnant patients with NMO (A) Interleukin.

Figure 2 Protective functions of HDL

Constantijn Franssen et al. JCHF 2016;4:

Volume 126, Issue 2, Pages (February 2004)

Systems medicine-based approaches in interstitial lung diseases seek to analyse biological products (e.g. Systems medicine-based approaches in interstitial.

Schematic representing the activation of the complement cascade.

Nat. Rev. Rheumatol. doi: /nrrheum

Systemic effects of local allergic disease

Time course of levels of serum C-reactive protein (CRP; normal < 5 mg/l) and procalcitonin (PCT; normal < 0.1 ng/ml). Time course of levels of serum C-reactive.

Response of Calu-6 tumors to anti-VEGF therapy.

Flow chart illustrating the hypothetical pathophysiology of the most striking histomorphologic features shown in electron micrographs of medulla obtained.

Measures of endothelial activation/dysfunction are associated with QRISK3. Measures of endothelial activation/dysfunction are associated with QRISK3. Increased.

Table 6. Serological markers in CD and inflammatory bowel disease

Presentation transcript:

Ability of biomarkers to predict small bowel inflammation in spondyloarthitis. Ability of biomarkers to predict small bowel inflammation in spondyloarthitis. SGI panel comprises these markers: serology — IgA and IgG ASCA, IgA OmpC, IBD-specific pANCA, DNA-sensitive pANCA, and antiflagellin antibodies (IgA CBir1, IgG anti-A4-Fla2, anti-FlaX); genetic — ATG16L1 SNP (rs2241880), EMC1 SNP (rs3737240), NKX2-3 SNP (rs10883365), and STAT3 SNP (rs744166); inflammation — ICAM-1, VCAM-1, VEGF, CRP, and SAA. SGI: serology, genetics, and inflammation; ASCA: anti-Saccharomyces cerevisiae antibodies; CRP: C-reactive protein; IBD: inflammatory bowel disease; ICAM-1: intercellular adhesion molecule; OmpC: anti-outer membrane porin C of E. coli; pANCA: perinuclear antineutrophil cytoplasmic antibody; SAA: serum amyloid A; SNP: single-nucleotide polymorphism; VCAM-1: vascular cell adhesion molecule; VEGF: vascular endothelial growth factor; NS: not significant. Uri Kopylov et al. J Rheumatol 2018;45:498-505 ©2018 by The Journal of Rheumatology