Volume 140, Issue 7, Pages (June 2011)

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Volume 140, Issue 7, Pages 1943-1951 (June 2011) The HTR3A Polymorphism c. -42C>T Is Associated With Amygdala Responsiveness in Patients With Irritable Bowel Syndrome Lisa A. Kilpatrick, Jennifer S. Labus, Kristen Coveleskie, Christian Hammer, Gudrun Rappold, Kirsten Tillisch, Joshua A. Bueller, Brandall Suyenobu, Johana M. Jarcho, Jim A. McRoberts, Beate Niesler, Emeran A. Mayer Gastroenterology Volume 140, Issue 7, Pages 1943-1951 (June 2011) DOI: 10.1053/j.gastro.2011.03.011 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 5-HT3R activation on GABAergic interneurons innervating the amygdala exerts an inhibitory influence on amygdala activity, whereas those on excitatory glutaminergic interneurons will exert an excitatory influence. Gastroenterology 2011 140, 1943-1951DOI: (10.1053/j.gastro.2011.03.011) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 (A) The emotional reactivity paradigm activated the amygdala. C/C genotype subjects, regardless of diagnosis, displayed increased amygdala responsiveness during the (B) ME condition and during the (C) MF condition. Gastroenterology 2011 140, 1943-1951DOI: (10.1053/j.gastro.2011.03.011) Copyright © 2011 AGA Institute Terms and Conditions

Figure 3 Mean and standard deviation for right amygdala emotional reactivity (defined as βME-MF) is plotted for healthy controls and IBS patients by HTR3A c.-42C>T genotype (C/C vs T carrier). A subset of IBS subjects with C/C genotype had an unusual pattern of amygdala response. Gastroenterology 2011 140, 1943-1951DOI: (10.1053/j.gastro.2011.03.011) Copyright © 2011 AGA Institute Terms and Conditions