Antibody-mediated gastrointestinal dysmotility in scleroderma Fiona Goldblatt, Tom P. Gordon, Sally A. Waterman  Gastroenterology  Volume 123, Issue 4, Pages 1144-1150 (October 2002) DOI: 10.1053/gast.2002.36057 Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 1 Raw traces showing contractile responses to cumulative addition of 1 –300 μmol/L carbachol in untreated tissue (upper trace) and after the addition of 1.0 mg/mL IgG from a patient with scleroderma (lower trace). Gastroenterology 2002 123, 1144-1150DOI: (10.1053/gast.2002.36057) Copyright © 2002 American Gastroenterological Association Terms and Conditions

Fig. 2 Responses to carbachol in the presence of Ig fraction from patients or healthy controls. Ig from a patient with scleroderma significantly inhibits carbachol-evoked responses at concentrations of (A) 0.3 mg/mL (P = 0.0002) and (B) 1 mg/mL (P < 0.0001). (C) IgG from a healthy control does not significantly alter carbachol-evoked responses (P > 0.05). (D) The maximum percentage inhibition of contractions evoked by 30 μmol/L carbachol with increasing concentrations of IgG from antibody-positive patients (n = 10) and healthy controls (n = 4) occurred at a concentration of 0.6 mg/mL. Gastroenterology 2002 123, 1144-1150DOI: (10.1053/gast.2002.36057) Copyright © 2002 American Gastroenterological Association Terms and Conditions