Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers Wenhsiang Wen, Wangjuh (Sting) Chen, Nick Xiao, Ryan.

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Mutations in the Kinase Domain of the HER2/ERBB2 Gene Identified in a Wide Variety of Human Cancers Wenhsiang Wen, Wangjuh (Sting) Chen, Nick Xiao, Ryan Bender, Anatole Ghazalpour, Zheng Tan, Jeffrey Swensen, Sherri Z. Millis, Gargi Basu, Zoran Gatalica, Michael F. Press The Journal of Molecular Diagnostics Volume 17, Issue 5, Pages 487-495 (September 2015) DOI: 10.1016/j.jmoldx.2015.04.003 Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 1 Patient distribution and relative frequency of the HER2 mutations by cancer type and lineage (frequency is only indicated in lineages with more than three mutations detected). The Journal of Molecular Diagnostics 2015 17, 487-495DOI: (10.1016/j.jmoldx.2015.04.003) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions

Figure 2 HER2 mutation spectrum in solid tumors. POS, HER2-positive by HER2 fluorescent in situ hybridization or HER2 overexpression by immunohistochemistry (3+). The Journal of Molecular Diagnostics 2015 17, 487-495DOI: (10.1016/j.jmoldx.2015.04.003) Copyright © 2015 American Society for Investigative Pathology and the Association for Molecular Pathology Terms and Conditions