Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane R. Sasaki, K. Hirota, S.H. Roth, M. Yamazaki

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Presentation transcript:

Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane R. Sasaki, K. Hirota, S.H. Roth, M. Yamazaki British Journal of Anaesthesia Volume 94, Issue 4, Pages 486-491 (April 2005) DOI: 10.1093/bja/aei077 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 1 Base-line trace of the field potential in the stratum pyramidale of CA1 before, during and after 3 min anoxia in the absence of anaesthetics and in the presence of thiopental 2×10−4 M, propofol 2×10−4 M and isoflurane 1.5 vol%. Representative examples show population spikes recorded in CA1 region evoked by stimulation of the Schaffer collateral before, during and after anoxia at each condition. The arrow indicates anoxic depolarization. British Journal of Anaesthesia 2005 94, 486-491DOI: (10.1093/bja/aei077) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 2 Incidence of AD induced by 3 min anoxia in each of the experimental groups. The incidence of AD was significantly lower in the group treated with thiopental 2×10−4 M (n=19) than in the groups treated with propofol 2×10−4 M (n=13) and isoflurane 1.5 vol% (n=10). *P=0.0001 vs untreated group (n=21) (Kruskal–Wallis test followed by Scheffé's method). British Journal of Anaesthesia 2005 94, 486-491DOI: (10.1093/bja/aei077) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 3 Relationship between the incidence of AD and anaesthetic concentration. Thiopental reduced the incidence of AD with increasing concentration (a), whereas all concentrations of propofol (b) and isoflurane (c) tested showed no change in the incidence of AD. *P<0.05 vs concentration of 10−4 M thiopental-treated group (Kruskal–Wallis test followed by Scheffé's method). British Journal of Anaesthesia 2005 94, 486-491DOI: (10.1093/bja/aei077) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 4 Relationship between the degree of recovery from 3 min anoxia and the duration of AD in the untreated group. The degree of recovery is expressed as a percentage of the pre-anoxic control value. The straight line was fitted by the equation y=98.7–0.22x; R=0.55, P=0.03 (n=17). British Journal of Anaesthesia 2005 94, 486-491DOI: (10.1093/bja/aei077) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions