Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious.

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Regional and temporal changes in cardiovascular responses to norepinephrine and vasopressin during continuous infusion of lipopolysaccharide in conscious rats Bennett T. , Mahajan R.P. , March J.E. , Kemp P.A. , Gardiner S.M. British Journal of Anaesthesia Volume 93, Issue 3, Pages 400-407 (September 2004) DOI: 10.1093/bja/aeh214 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 Changes in cardiovascular variables during a 24-h infusion of saline or LPS in rats challenged with NE or AVP at 2, 6, and 24 h after the onset of infusion. Values are mean (sem); n=7 or 8 animals/group. *P<0.05 vs baseline (Friedman's test). British Journal of Anaesthesia 2004 93, 400-407DOI: (10.1093/bja/aeh214) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Integrated (0–3 min areas under or over curves) cardiovascular responses to NE at 2, 6, and 24 h after the onset of infusion of saline or LPS infusion. Data (mean (sem)) are expressed as absolute changes (left hand panels) or percentage changes (right hand panels) for low dose (L), middle dose (M), and high dose (H) of NE (75, 250, and 750 ng kg−1 min−1, respectively). *A significant difference (P<0.05, Kruskal–Wallis test) between saline and LPS-infused groups at specific time-points. British Journal of Anaesthesia 2004 93, 400-407DOI: (10.1093/bja/aeh214) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 3 Integrated (0–3 min areas under or over curves) cardiovascular responses to AVP (triangles) at 2, 6, and 24 h after the onset of infusion of saline (closed symbols) or LPS (open symbols) infusion. Data (mean (sem)) are expressed as absolute changes (left hand panels) or percentage changes (right hand panels) for low dose (L), middle dose (M), and high dose (H) of AVP (0.25, 0.625 and 1.25 ng kg−1 min−1, respectively). *A significant difference (P<0.05, Kruskal–Wallis test) between saline and LPS-infused groups at specific time-points. British Journal of Anaesthesia 2004 93, 400-407DOI: (10.1093/bja/aeh214) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 4 Integrated (0–3 min areas under or over curves) cardiovascular responses to NE (250 ng kg−1 min−1) or AVP (1.25 ng kg−1 min−1) at 2, 6, and 24 h after the onset of infusion of LPS. Data (mean (sem)) are expressed as percentage of the corresponding value in saline-infused animals. *A significant difference (P<0.05, Kruskal–Wallis test) from the saline group. British Journal of Anaesthesia 2004 93, 400-407DOI: (10.1093/bja/aeh214) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions