Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts Satoshi Yamashiro, MDa,b, Katsuhiko Noguchi,

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Presentation transcript:

Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts Satoshi Yamashiro, MDa,b, Katsuhiko Noguchi, PhDa, Toshihiro Matsuzaki, MD, PhDa, Kanako Miyagi, BSa, Junko Nakasone, PhDa, Mayuko Sakanashi, MSa, Kageharu Koja, MD, PhDb, Matao Sakanashi, MD, PhDa The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 4, Pages 775-784 (October 2002) DOI: 10.1067/mtc.2002.124393 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Time course of changes in LVDP (A), mean CF (B), maximum LV dp/dt (C), and minimum LV dp/dt (D) in the nonischemic KHS group (n = 8, open triangles), the nonischemic BH4 group (n = 8, filled triangles), the ischemic KHS group (n = 8, open circles), the ischemic BH4 (1.25 mg/mL) group (n = 8, filled circles), the ischemic low BH4 (0.6 mg/mL) group (n = 8, open diamonds), the Vit C (0.49 mg/mL) group (n = 6, filled diamonds), and the SOD/catalase (2000 U/mL each) group (n = 8, open squares). Values are expressed as percentages of corresponding baseline values. Each value represents mean ± SE. ***P <.001 versus ischemic KHS group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 775-784DOI: (10.1067/mtc.2002.124393) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Time course of change in LVEDP (A), time to onset of ischemic contracture (B), and peak LVEDP during ischemia (C). Each value represents mean ± SE. *P <.05, **P <.01, and ***P <.001 versus ischemic KHS group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 775-784DOI: (10.1067/mtc.2002.124393) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 LDH activity in coronary effluent in the nonischemic KHS group (n = 7), the nonischemic BH4 group (n = 7), the ischemic KHS group (n = 7), the ischemic BH4 group (n = 7), the ischemic low BH4 group (n = 7), the Vit C group (n = 6), and the SOD/catalase group (n = 8). Each value represents mean ± SE. NS, No significant difference. ***P <.001 versus ischemic KHS group; †P <.05 and †††P <.001 versus nonischemic KHS group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 775-784DOI: (10.1067/mtc.2002.124393) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Percentage of NOx level in the coronary effluent after ischemia. Values are expressed as percentages of corresponding baseline values before ischemia. Each value represents mean ± SE. ***P <.001 versus ischemic KHS group; ††P <.01 and †††P <.001 versus nonischemic KHS group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 775-784DOI: (10.1067/mtc.2002.124393) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions