Lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity Karin C. Lødrup Carlsen, MD, PhD, Petter Mowinckel,

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Presentation transcript:

Lung function trajectories from birth through puberty reflect asthma phenotypes with allergic comorbidity Karin C. Lødrup Carlsen, MD, PhD, Petter Mowinckel, MSc, Vegard Hovland, MD, Geir Håland, MD, PhD, Amund Riiser, MSc, PhD, Kai- Håkon Carlsen, MD, PhD Journal of Allergy and Clinical Immunology Volume 134, Issue 4, Pages 917-923.e7 (October 2014) DOI: 10.1016/j.jaci.2014.05.020 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Lung function trajectories from birth (by tPTEF/tE) through age 10 and 16 years for FEV1 are given as z scores in the reference group (children who never had rBO by age 2 years or asthma later) and in children with asthma (A and B). In A, the trajectories are given by children with rBO or asthma only before age 10 years versus children with asthma after age 10 years, whereas in B, the trajectories are given by children with rBO or asthma at any time up to age 16 years who were not sensitized to any allergen at age 16 years and those with asthma (or rBO) who were sensitized to at least 1 allergen. The trajectories in children with asthma were significantly different from those in the reference group, but without significant differences related to the time of asthma presentation (Fig 1, A) or allergic sensitization (Fig 1, B). Journal of Allergy and Clinical Immunology 2014 134, 917-923.e7DOI: (10.1016/j.jaci.2014.05.020) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Lung function trajectories (by z scores from birth through age 10 to 16 years) by asthma phenotypes based on comorbidities determined by age 16 years by FEV1, (left), the midflow value (FEF25-75) (center), and FEV1/FVC (right). The trajectories were significantly reduced in children with asthma, AD, and AR than in children with all other combinations of allergic diseases. Journal of Allergy and Clinical Immunology 2014 134, 917-923.e7DOI: (10.1016/j.jaci.2014.05.020) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Lung function trajectories from birth (by tPTEF/tE) through age 10 and 16 years for the midflow value (FEF25-75) (A and B) and FEV1/FVC (C and D) as z scores in the reference group (children who never had rBO by 2 years or asthma later) and in children with asthma. In Fig E1 (A and C), the trajectories are given by children with rBO or asthma only before age 10 years versus children with asthma after age 10 years, whereas in Fig E1 (B and D), the trajectories are given by children with rBO or asthma at any time up to 16 years who were not sensitized to any allergen at 16 years and those with asthma (or rBO) who were sensitized to at least 1 allergen. The trajectories in children with asthma were significantly different from those in the reference group, but without significant differences related to the time of asthma presentation (Fig E1, A and C) or allergic sensitization (Fig E1, B and D). Journal of Allergy and Clinical Immunology 2014 134, 917-923.e7DOI: (10.1016/j.jaci.2014.05.020) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Lung function trajectories (by z scores from birth through age 10-16 years for baseline lung function) by asthma phenotypes based on the time of asthma presentation determined by age 16 years are given for FEV1 (left), the midflow value (FEF25-75) (center), and FEV1/FVC (right). Journal of Allergy and Clinical Immunology 2014 134, 917-923.e7DOI: (10.1016/j.jaci.2014.05.020) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions