Natural and hybrid (“chimeric”) stable regulatory glyproline peptides I.P. Ashmarin, G.E. Samonina, L.A. Lyapina, A.A. Kamenskii, N.G. Levitskaya, I.A. Grivennikov, O.V. Dolotov, L.A. Andreeva, N.F. Myasoedov  Pathophysiology  Volume 11, Issue 4, Pages 179-185 (May 2005) DOI: 10.1016/j.pathophys.2004.10.001 Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 PGP and its metabolites – PG and GP quantity and percent of administered radioactivity in rabbit's blood plasma after different ways of administration. Y-axis: peptide's concentration, μM; Z-axis: percent of administrated radioactivity. IP, intraperitoneal; IG, intragastric; II, intraintestinal administration. Pathophysiology 2005 11, 179-185DOI: (10.1016/j.pathophys.2004.10.001) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 Antiulcer effects of intraperitoneal and intragastric administrations of PGP at ethanol-induced damages in rats. Y-axis: cumulative area of gastric mucosa damages in mm2; X-axis: doses of PGP, mg/kg. IP, intraperitoneal; IG, intragastric administration. Statistical analysis was performed using LSD test. Statistically significant difference from control at *p<0.05. Pathophysiology 2005 11, 179-185DOI: (10.1016/j.pathophys.2004.10.001) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 3 Comparison of the anticlotting effects after 1h intraperitoneal introduction of PGP and PG in dose 1mg/kg of body weight of rats (control=100%). The haemostatic parameters of blood plasma: t-PA, activity of plasminogen activator; AP, platelet aggregation; FXIIIa, the activity of factor XIIIa. Pathophysiology 2005 11, 179-185DOI: (10.1016/j.pathophys.2004.10.001) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 4 Comparison of the anticlotting effects after intragastric introduction of PGP and PG to rats for 10 days, 1mg/kg daily (control=100%). The haemostatic parameters of blood plasma: t-PA, activity of plasminogen activator; AP, aggregation of platelet; FXIIIa, activity of factor XIIIa. Pathophysiology 2005 11, 179-185DOI: (10.1016/j.pathophys.2004.10.001) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 5 The thrombus weights after the action of PGP and semax. Y-axis, percent to control (NaCl). Pathophysiology 2005 11, 179-185DOI: (10.1016/j.pathophys.2004.10.001) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions

Fig. 6 Influence of semax (100nM) on the BDNF and NGF mRNA levels in the rat basal forebrain neuroglial cells in vitro (semi-quantitative RT-PCR data). X-axis: time, h; Y-axis: mRNA level, percent of control. Pathophysiology 2005 11, 179-185DOI: (10.1016/j.pathophys.2004.10.001) Copyright © 2004 Elsevier Ireland Ltd Terms and Conditions