Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat.

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International Neurourology Journal 2014;18:

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Presentation transcript:

Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat model of transient global cerebral ischaemia H. Lee, Y.H. Park, Y.T. Jeon, J.W. Hwang, Y.J. Lim, E. Kim, S.Y. Park, H.P. Park British Journal of Anaesthesia Volume 114, Issue 2, Pages 307-318 (February 2015) DOI: 10.1093/bja/aeu268 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 Experiment protocol. Sevo, sevoflurane. British Journal of Anaesthesia 2015 114, 307-318DOI: (10.1093/bja/aeu268) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 (a) Representative photomicrographs from a single animal showing necrotic and viable cells in the hippocampal CA1 regions on days 1 and 7 after transient global cerebral ischaemia. (b) Percentages of necrotic cells in the hippocampal CA1 region days 1 and 7 after ischaemia (H&E staining). Results are given as median, inter-quartile, and full ranges. *P<0.01 vs the sham group. †P<0.01 vs the control and chelerythrine groups. ‡P<0.01 vs the sevoflurane post-conditioning group. #P<0.05 vs the control and chelerythrine groups. ##P<0.01 vs day 1. H&E, haematoxylin and eosin; CA1, Cornu Ammonis area 1; Sevo, sevoflurane; postC, post-conditioning; Che, chelerythrine. British Journal of Anaesthesia 2015 114, 307-318DOI: (10.1093/bja/aeu268) Copyright © 2015 The Author(s) Terms and Conditions

Fig 3 (a) Representative photomicrographs from a single animal of TUNEL staining showing apoptotic cells in the hippocampal CA1 region on days 1 and 7 after transient global cerebral ischaemia. (b) Percentages of apoptotic cells in the hippocampal CA1 region days 1 and 7 after ischaemia (TUNEL staining). Results are given as median, inter-quartile, and full ranges. *P<0.01 vs the sham group. †P<0.01 vs the control and chelerythrine groups. ‡P<0.01 vs the sevoflurane post-conditioning group. ##P<0.01 vs day 1. TUNEL, terminal deoxynucleotidyl transferase-mediated deoxy-uracil triphosphate biotin in situ nick end-labelling; CA1, Cornu Ammonis area 1; Sevo, sevoflurane; postC, post-conditioning; Che, chelerythrine. British Journal of Anaesthesia 2015 114, 307-318DOI: (10.1093/bja/aeu268) Copyright © 2015 The Author(s) Terms and Conditions

Fig 4 (a) Representative western blot analysis of nuclear Nrf2 from a single animal on days 1 and 7 after transient global cerebral ischaemia in rats. (b) Densitometric evaluation of nuclear Nrf2. Results are given as median, inter-quartile, and full ranges. Histone H3 was used as a control. *P<0.01 vs the sham group. †P<0.01 vs the control and chelerythrine groups. ‡P<0.01 vs the sevoflurane post-conditioning group. ##P<0.01 vs day 1. Nrf2, nuclear factor erythroid 2-related factor 2; Sevo, sevoflurane; postC, post-conditioning; Che, chelerythrine. British Journal of Anaesthesia 2015 114, 307-318DOI: (10.1093/bja/aeu268) Copyright © 2015 The Author(s) Terms and Conditions

Fig 5 (a) Representative western blot analysis of HO-1 from a single animal on days 1 and 7 after transient global cerebral ischaemia. (b) Densitometric evaluation of HO-1 protein expression. Results are median, inter-quartile, and full ranges. β-Actin was used as a control. *P<0.01 vs the sham group. †P<0.01 vs the control and chelerythrine groups. ‡P<0.01 vs the sevoflurane post-conditioning group. ##P<0.01 vs day 1. HO-1, haemoxygenase-1; Sevo, sevoflurane; postC, post-conditioning; Che, chelerythrine. British Journal of Anaesthesia 2015 114, 307-318DOI: (10.1093/bja/aeu268) Copyright © 2015 The Author(s) Terms and Conditions

Fig 6 (a) Representative western blot analysis of caspase 3 from a single animal on days 1 and 7 after transient global cerebral ischaemia. (b) Densitometric evaluation of caspase-3 protein expression. Results are given as median, inter-quartile, and full ranges. β-Actin was used as a control. *P < 0.01 vs the sham group. †P<0.01 vs the control and chelerythrine groups. ‡P<0.01 vs the sevoflurane post-conditioning group. #P<0.05 vs the control group. ##P<0.01 vs day 1. Sevo, sevoflurane; postC, post-conditioning; Che, chelerythrine. British Journal of Anaesthesia 2015 114, 307-318DOI: (10.1093/bja/aeu268) Copyright © 2015 The Author(s) Terms and Conditions