Arresting Cancer Proliferation by Small-Molecule Gene Regulation

Slides:

Advertisements

Similar presentations

Halogen Bonds Form the Basis for Selective P-TEFb Inhibition by DRB Sonja Baumli, Jane A. Endicott, Louise N. Johnson Chemistry & Biology Volume 17, Issue.

Advertisements

Development of Antibiotic Activity Profile Screening for the Classification and Discovery of Natural Product Antibiotics Weng Ruh Wong, Allen G. Oliver,

Regulation of Telomere Length by G-Quadruplex Telomere DNA- and TERRA-Binding Protein TLS/FUS Kentaro Takahama, Asami Takada, Shota Tada, Mai Shimizu,

Proteasome Inhibition by Fellutamide B Induces Nerve Growth Factor Synthesis John Hines, Michael Groll, Margaret Fahnestock, Craig M. Crews Chemistry &

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis Tim J. Wigle, Laurel M. Provencher, Jacqueline.

In Vivo Photoswitchable Flow Cytometry for Direct Tracking of Single Circulating Tumor Cells Dmitry A. Nedosekin, Vladislav V. Verkhusha, Alexander V.

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking Peter Daldrop, Francis E. Reyes, David A. Robinson, Colin M. Hammond, David M. Lilley,

A Dumbbell-Shaped Small Molecule that Promotes Cell Adhesion and Growth Sayumi Yamazoe, Hiroki Shimogawa, Shin-ichi Sato, Jeffrey D. Esko, Motonari Uesugi.

Biocompatible Quantum Dots for Biological Applications Sandra J. Rosenthal, Jerry C. Chang, Oleg Kovtun, James R. McBride, Ian D. Tomlinson Chemistry &

DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs Yves Pommier, Elisabetta Leo, HongLiang Zhang, Christophe Marchand Chemistry.

Proteasome Inhibitors: An Expanding Army Attacking a Unique Target Alexei F. Kisselev, Wouter A. van der Linden, Herman S. Overkleeft Chemistry & Biology.

The Microbiome and Cancer: Is the ‘Oncobiome’ Mirage Real? Ryan M. Thomas, Christian Jobin Trends in Cancer Volume 1, Issue 1, Pages (September 2015)

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria Alban Pereira, Zhengyu Cao, Thomas.

Context-Specific Target Definition in Influenza A Virus Hemagglutinin-Glycan Receptor Interactions Zachary Shriver, Rahul Raman, Karthik Viswanathan, Ram.

Staphylococcus aureus and Bacillus subtilis W23 Make Polyribitol Wall Teichoic Acids Using Different Enzymatic Pathways Stephanie Brown, Timothy Meredith,

Synthesis and Testing of a Focused Phenothiazine Library for Binding to HIV-1 TAR RNA Moriz Mayer, P. Therese Lang, Sabina Gerber, Peter B. Madrid, Irene.

The Efficacy of siRNAs against Hepatitis C Virus Is Strongly Influenced by Structure and Target Site Accessibility Selena M. Sagan, Neda Nasheri, Christian.

Small Molecule Inhibitors of Clostridium difficile Toxin B-Induced Cellular Damage John Tam, Greg L. Beilhartz, Anick Auger, Pulkit Gupta, Alex G. Therien,

Glycosidase Inhibition by Macrolide Antibiotics Elucidated by STD-NMR Spectroscopy Ali Sadeghi-Khomami, Michael D. Lumsden, David L. Jakeman Chemistry.

Functional Studies of Plasmodium falciparum Dipeptidyl Aminopeptidase I Using Small Molecule Inhibitors and Active Site Probes Edgar Deu, Melissa J. Leyva,

Nucleosomes and Cisplatin

Volume 22, Issue 5, Pages v-vi (May 2015)

Now Playing: Farnesol in the Biofilm

Enzyme Annotation with Chemical Tools

New Light on Methylthiolation Reactions

DNMT1 and Cancer: An Electrifying Link

Tailor-Made Peptide Synthetases

Nucleosomes and Cisplatin

On-Bead Library Screening Made Easier

Antibiotics: A New Hope

Foundations for Directed Alkaloid Biosynthesis

Arresting Cancer Proliferation by Small-Molecule Gene Regulation

Ribosome Evolution for Two Artificial Amino Acids in E. coli

Nature’s Strategy for Catalyzing Diels-Alder Reaction

Scratch n’ Screen for Inhibitors of Cell Migration

Chemical Proteomics of Host-Pathogen Interaction

Designing Effective Hybrid Toxins

In Search of the Missing Ligands for TetR Family Regulators

Adding Specificity to Artificial Transcription Activators

Finding the Missing Code of RNA Recognition by PUF Proteins

News in Ubiquinone Biosynthesis

Activity-Based Profiling of 2-Oxoglutarate Oxygenases

Targeting the Undruggable Proteome: The Small Molecules of My Dreams

A Noncanonical Path to Mechanism of Action

Bioactive Cell-Penetrating Peptides: Kill Two Birds with One Stone

No Need To Be Pure: Mix the Cultures!

A Trojan Horse for Human Immunodeficiency Virus

Activity-Based Profiling for Drug Discovery

Now Playing: Farnesol in the Biofilm

Ribosome Evolution for Two Artificial Amino Acids in E. coli

HAT Trick: p300, Small Molecule, Inhibitor

BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

Accessibility of Nuclear Chromatin by DNA Binding Polyamides

Volume 21, Issue 8, Pages v-vi (August 2014)

Foundations for Directed Alkaloid Biosynthesis

Discrimination between Two Endocannabinoids

Redesigning the Architecture of the Base Pair: Toward Biochemical and Biological Function of New Genetic Sets Andrew T. Krueger, Eric T. Kool Chemistry.

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

Nature’s Strategy for Catalyzing Diels-Alder Reaction

L-DOPA Ropes in tRNAPhe

Fine-Tuning ER-β Structure with PTMs

Harnessing the Antioxidant Power with ARE-Inducing Compounds

Volume 21, Issue 9, Pages (September 2014)

Self-Assembling, Dynamic αPNAs

Tools to Tackle Protein Acetylation

Nicholas R Wurtz, Peter B Dervan Chemistry & Biology

Volume 21, Issue 9, Pages (September 2014)

A New Fluorescence-Based Assay for Autophagy

Volume 18, Issue 5, Pages R198-R202 (March 2008)

Volume 22, Issue 4, Pages vii-viii (April 2015)

Presentation transcript:

Arresting Cancer Proliferation by Small-Molecule Gene Regulation Liliane A. Dickinson, Ryan Burnett, Christian Melander, Benjamin S. Edelson, Paramjit S. Arora, Peter B. Dervan, Joel M. Gottesfeld Chemistry & Biology Volume 13, Issue 3, (March 2006) DOI: 10.1016/j.chembiol.2006.02.006 Copyright © 2006 Elsevier Ltd Terms and Conditions

Figure 1 Polyamide Conjugate Structure 1R-Chl = ImIm-β-Im-α(R-2,4-DABAChl)-PyPyPyPy-β-Dp, in which Py is pyrrole, Im is imidazole, β is β-alanine, Dp is dimethylaminopropylamine, and 2,4-DABA is (R)-2,4-diaminobutyric acid with α describing the amino acid linking the polyamide and Chl describing the chlorambucil substituent at the 4-amino position. Chemistry & Biology 2006 13, DOI: (10.1016/j.chembiol.2006.02.006) Copyright © 2006 Elsevier Ltd Terms and Conditions