How do equivalent cells acquire different cell fates?

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How do equivalent cells acquire different cell fates?

What is the major issue that the authors tried to address? LIN-12 and Notch are similar proteins LIN-12 acts differently from Notch LIN-12 or Notch intracellular domain has an intrinsic biological activity How LIN-12 intracellular domain act to affect cell fate How Notch works in Drosophila

LIN-12(intra) acts like An activated LIN-12 A LIN-12 mutant without an activity A protein that gains a new function A protein that needs to act through another protein A protein that act through the endogenous LIN-12 protein

Delta is A Notch-like receptor A putative Notch ligand A protein that acts downstream of Notch A protein that antagonizes Notch activity None of the above

Notch is a membrane protein can be in the nucleus acts downstream of Delta Normally suppresses the neural fate All of the above

What did you really learn from reading this paper? How neurogenesis is regulated in flies How vulva development is regulated in worms. Notch and LIN-12 have a conserved acting mechanism LIN-12 and Notch look alike in structure All of the above

What is the most interesting question that is not resolved in this paper? How does LIN-12 specify the AC and VU cell fate? How does Notch suppress the neural fate? How do Notch and LIN-12 acquire a conserved acting mechanism How do LIN-12 and Notch evolve to have similar structures Why is Notch observed on both plasma membrane and the nucleus?