Effect of bolus and divided feeding on urine ions and supersaturation in genetic hypercalciuric stone-forming rats D.A. Bushinsky, A.C. Michalenka, K.L.

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Presentation transcript:

Effect of bolus and divided feeding on urine ions and supersaturation in genetic hypercalciuric stone-forming rats D.A. Bushinsky, A.C. Michalenka, K.L. Strutz, S. Donahue, J.R. Asplin Kidney International Volume 73, Issue 4, Pages 423-429 (February 2008) DOI: 10.1038/sj.ki.5002699 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Urine calcium excretion during three different time periods while genetic hypercalciuric stone-forming rats were fed either a normal (1.2%) or low (0.02%) Ca diet. Twenty-four seventy-first generation female GHS rats were divided into two groups and placed in metabolic cages. Throughout days 1–14, each rat in each group was fed 13 g per day of a normal Ca diet. One group received their daily food allotment as a bolus at time 0 (Bolus), and the other group received their allotment divided into three (Div) portions at 0, 6, and 9 h. All bolus-fed rats completely consumed the food within 15 min of food presentation. During the last 4 days of this period (days 11–14), successive urine collections were obtained 0–3, 3–6, and 6–24 h. Throughout days 15–28, each rat in each group was fed 13 g per day of a low Ca diet. Rats were fed in the same groups as assigned in days 1–14. During the last 4 days of this period, successive urine collections were obtained as during days 11–14. *P<0.05 vs Bolus, same time period. Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 2 Urine oxalate excretion. Protocol and abbreviations as in Figure 1. Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 3 Urine phosphorus excretion. Protocol and abbreviations as in Figure 1. Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 4 Urine pH. Protocol and abbreviations as in Figure 1. 127 × 190 mm (300 × 300 d.p.i.). Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 5 Urine volume. Protocol and abbreviations as in Figure 1. Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 6 Urine supersaturation with respect to the calcium oxalate (CaOx) solid phase. Protocol and abbreviations as in Figure 1. *P<0.05 vs Bolus, same time period; °P<0.05 vs 0–3 h time period, same group; #P<0.05 vs 3–6 h time period same group. Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 7 Urine supersaturation with respect to the calcium hydrogen phosphate (CaHPO4, brushite) solid phase. Protocol and abbreviations as in Figure 1. *P<0.05 vs Bolus, same time period; °P<0.05 vs 0–3 h time period, same group; #P<0.05 vs 3–6 h time period, same group. Kidney International 2008 73, 423-429DOI: (10.1038/sj.ki.5002699) Copyright © 2008 International Society of Nephrology Terms and Conditions