Integrating clinical, dermoscopy, and reflectance confocal microscopy findings into correctly identifying a nevoid melanoma Manu Jain, MD, Ashfaq A.

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Presentation transcript:

Integrating clinical, dermoscopy, and reflectance confocal microscopy findings into correctly identifying a nevoid melanoma Manu Jain, MD, Ashfaq A. Marghoob, MD JAAD Case Reports Volume 3, Issue 6, Pages 505-508 (November 2017) DOI: 10.1016/j.jdcr.2017.08.006 Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 A, Clinical image showing a 9-mm, brownish-pink, slightly mamillated lesion. B, Dermoscopy image showing atypical vessels (arrows) and irregular globules (arrowheads). JAAD Case Reports 2017 3, 505-508DOI: (10.1016/j.jdcr.2017.08.006) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Reflectance confocal microcopy mosaic (∼6.5 mm × 8 mm) of nevoid melanoma acquired at the stratum spinosum and dermoepidermal junction showing a slightly papillated, well-circumscribed, asymmetric lesion. The epidermis has a regular honeycomb pattern (green asterisks) without any prominent pagetosis. Multiple large, irregularly sized and shaped nests (red asterisks) are seen at the dermoepidermal junction. The inset in red (∼1 mm × 1 mm) shows the nonhomogenous, dense and sparse nature of these nests. The dotted-green box within the inset shows cytologic atypia (red arrowheads) within the melanocytic nests at a higher magnification. (Original magnifications: ∼×2; red inset, ∼×15.) JAAD Case Reports 2017 3, 505-508DOI: (10.1016/j.jdcr.2017.08.006) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Histopathology image of a nevoid melanoma showing a well-circumscribed but asymmetric melanocytic lesion with junctional and dermal nests (red arrowheads). The inset shows cytologic and nuclear atypia in the melanocytic cells. (Hematoxylin-eosin stain; original magnifications: ×4; inset, ×20.) JAAD Case Reports 2017 3, 505-508DOI: (10.1016/j.jdcr.2017.08.006) Copyright © 2017 American Academy of Dermatology, Inc. Terms and Conditions