Insulin Transport within Skeletal Muscle Transverse Tubule Networks

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Insulin Transport within Skeletal Muscle Transverse Tubule Networks P.R. Shorten, C.D. McMahon, T.K. Soboleva Biophysical Journal Volume 93, Issue 9, Pages 3001-3007 (November 2007) DOI: 10.1529/biophysj.107.107888 Copyright © 2007 The Biophysical Society Terms and Conditions

Figure 1 A reconstruction of the t-tubule network made by Peachey and Eisenberg (3) using electron microscope slices of frog sartorius muscle fibers (×1400; fiber is ∼40×80μm). The boundary of the t-tubule network represents the sarcolemma. Reprinted with permission from the Biophysical Society and L. D. Peachey. Biophysical Journal 2007 93, 3001-3007DOI: (10.1529/biophysj.107.107888) Copyright © 2007 The Biophysical Society Terms and Conditions

Figure 2 The simulated insulin transport within the t-tubules of a 40-μm-diameter skeletal muscle fiber with circular cross section after insulin bolus injection (1.87nM) at 0, 2, 5, 10, 15, and 20μm from the sarcolemma. The horizontal line denotes the equilibrium insulin concentration. Biophysical Journal 2007 93, 3001-3007DOI: (10.1529/biophysj.107.107888) Copyright © 2007 The Biophysical Society Terms and Conditions

Figure 3 The simulated insulin concentration gradient within the t-tubules of a 40-μm-diameter skeletal muscle fiber with circular cross section after insulin bolus injection (1.87nM) at 0, 5, 60, 240, 480, and 720s. Biophysical Journal 2007 93, 3001-3007DOI: (10.1529/biophysj.107.107888) Copyright © 2007 The Biophysical Society Terms and Conditions

Figure 4 The simulated concentrations of bound insulin receptors within the t-tubules of a 40-μm-diameter skeletal muscle fiber after insulin bolus injection (1.87nM) at 0, 1, 5, 60, 240, 480, and 720s. Biophysical Journal 2007 93, 3001-3007DOI: (10.1529/biophysj.107.107888) Copyright © 2007 The Biophysical Society Terms and Conditions

Figure 5 The predicted times for insulin to reach 0.75nM at a location 20μm from the sarcolemma after the insulin injection as a function of muscle fiber composition. The skeletal muscles are rat adductor longus (○), soleus (X), quadriceps (□), EDL (*), anterior tibialis (+), and medial gastrocnemius (▵). Also shown is a linear regression fit to these insulin travel times that explains 90% of the variance (—). Biophysical Journal 2007 93, 3001-3007DOI: (10.1529/biophysj.107.107888) Copyright © 2007 The Biophysical Society Terms and Conditions