“Default” versus “pre-atopic” IgG responses to foodborne and airborne pathogenesis- related group 10 protein molecules in birch-sensitized and nonatopic.

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Presentation transcript:

“Default” versus “pre-atopic” IgG responses to foodborne and airborne pathogenesis- related group 10 protein molecules in birch-sensitized and nonatopic children Stephanie Hofmaier, Laura Hatzler, MD, Alexander Rohrbach, Valentina Panetta, MSc, Dani Hakimeh, MD, Carl Peter Bauer, MD, Ute Hoffman, MD, Johannes Forster, MD, Fred Zepp, MD, Antje Schuster, MD, Philippe Stock, MD, Ulrich Wahn, MD, Thomas Keil, MD, Susanne Lau, MD, Paolo Maria Matricardi, MD Journal of Allergy and Clinical Immunology Volume 135, Issue 5, Pages 1367-1374.e8 (May 2015) DOI: 10.1016/j.jaci.2014.09.048 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Prevalence and concentration of IgE and IgG to 10 PR-10 molecules from birth to 13 years in 28 children with birch atopy (A, B, D, E) and 28 nonatopic children (C and F). Levels of IgG and IgE antibodies are geometric mean values of ISU of positive sera for IgE (cutoff ≥0.3 ISU) or for IgG (cutoff ≥0.1 ISU). Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Analysis of the onset of antibody responses to PR-10 molecules in 28 children with birch atopy. A, Cumulative distribution of the age at first detection of an IgG and IgE response to Bet v 1. B, Relationship of the age at first detection of IgE to foodborne PR-10 molecules and the degree of homology with Bet v 1 (primary sequence). Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Correlation between the degree of sequence homology with Bet v 1 of foodborne PR-10 molecules and the prevalences or levels of the respective IgE or IgG antibodies by group and age. Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Proportion of subjects with an IgG response to foodborne PR-10 molecules, which is paralleled by an IgG response to Bet v 1, by age. Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Selection process of participants. Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Trends of antibody levels to PR-10 molecules in 1 child with birch atopy (A, IgE; B, IgG) and 1 nonatopic subject (C, IgG). Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Antigen-specific inhibition curve of the serum IgG response to Pru p 1 of a nonatopic subject. Journal of Allergy and Clinical Immunology 2015 135, 1367-1374.e8DOI: (10.1016/j.jaci.2014.09.048) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions