G. Plumton, I. Adjei, A. Martin-Pena, G.D. Palmer, B. Sharma

Slides:

Advertisements

Similar presentations

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Advertisements

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Synovial mesenchymal stem cells from “super-healer” mice directly contribute to articular cartilage regeneration C.L. Jablonski, J. Mak, C. Leonard,

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis P.

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

Fully-automated cartilage segmentation from magnetic resonance images of the knee using atlas and graph-cut algorithms J.-G. Lee, S. Gumus, K.C. Kwoh,

S. Gavard Osteoarthritis and Cartilage

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Injectable hydrogels for cartilage repair

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Characterization of cartilage repair in a focal mouse defect model

Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative M.A. Bowes, C.B. Wolstenholme,

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis

Prevention and treatment of intervertebral disc degeneration with bone marrow derived stem (stromal) cells – an in vivo study in sheep C.C. Shu, A. Dart,

Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells J. Mason, A. Donahue, A. Yoskowitz, D. Richardson

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Transcription factor SPB-x is a key molecule inducing hypertrophy of differentiated chondrocyte from MSC G.-I. Im, J.-M. Lee, J.-M. Ahn, E.-A. Kim Osteoarthritis.

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

Multifunctional nanoparticles for improving function and multimodal tracking of mesenchymal stem cells for osteoarthritis treatment I.M. Adjei, H. Yang,

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

G. R. Dodge, A. J. Farran, R. Cocca, G. Meloni, B. Mohanraj, A

High flexion is associated with knee osteoarthritis - of four high flexion postures, flat foot squatting minimizes knee adduction moments H.C. Chong,

Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes H. Inoue, Y. Arai, R. Terauchi, S. Nakagawa,

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

The differences on extracellular matrix among each portion of meniscus

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis P.

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study J. Podlipská, P. Kaukinen,

Y. Zhou, L. Resutek, L. Wang, X. Lu Osteoarthritis and Cartilage

R. Nakamura, N. Komatsu, K. Fujita, H. Nishimura, Y. Katsuki

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Two different knee braces alter patella position: a moving image analysis using weight bearing magnetic resonance imaging M.J. Callaghan, N.D. Reeves,

The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties M. Nickien,

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Regionally distinct f-actin networks within articular cartilage

D.D. Anderson, A.M. Kern, T.J. Stockman, C.M. Findlay, N.A. Segal

Cell surface receptor expression profile of human synovial mesenchymal stem cells in- vivo predicts their differentiation potential in-vitro N.U. Aljezani,

Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan,

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

G. van den Akker, T. Welting, D. Surtel, A. Cremers, W. Voncken, L

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Development of growth factor tethered hyaluronan microspheres for in situ chondrogenic differentiation of human mesenchymal stem cells S. Ansboro, J.S.

R. L. Trevino, C. A. Pacione, S. Chubinskaya, A. -M. Malfait, M. A

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

A peptide temporally enhanced chondrogenesis of mesenchymal stem cells

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

S. Brown, J. Pistiner, B. Sharma Osteoarthritis and Cartilage

G. Desando, I. Bartolotti, C. Cavallo, A. Schiavinato, E. Kon, G

Dancing transcription factors: What makes SOX9 move?

The elastic modulus of articular cartilage at nano-scale and micro-scale measured using indentation type atomic force microscopy P. Rahnamay Moshtagh,

J.H. Ylärinne, C. Qu, M.J. Lammi Osteoarthritis and Cartilage

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

Adipose derived stromal cells encapsulation in hydrogel particles: potential application to osteoarthritis F. Hached, C. Vinatier, P.-G. Pinta, P. Weiss,

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

Fully automated segmentation of cartilage from magnetic resonance images using improved 3D shape context and active shape model T. Ye, X. Cui, H. Kim

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Macroporous 3D scaffolds for studying MSC migration and differentiation within cartilage defects G. Plumton, I. Adjei, A. Martin-Pena, G.D. Palmer, B. Sharma Osteoarthritis and Cartilage Volume 24, Pages S162-S163 (April 2016) DOI: 10.1016/j.joca.2016.01.320 Copyright © 2016 Terms and Conditions

Figure 1 SEM Image of nanoporous and macroporoushydrogels. 0%, 10%, 20%, and 30% weight per volume gelatin microspheres (diamter 150–300 μm were suspended in solution to demonstrate variable porosity and architecture. Osteoarthritis and Cartilage 2016 24, S162-S163DOI: (10.1016/j.joca.2016.01.320) Copyright © 2016 Terms and Conditions

Figure 2. Luminosity at three time points of cell media containing secreted luciferase produced by transfected cells. No luminosity registered in the control groups without virus. Osteoarthritis and Cartilage 2016 24, S162-S163DOI: (10.1016/j.joca.2016.01.320) Copyright © 2016 Terms and Conditions

Figure 3 Left: GFP fluorescing cells (green)in a macroporoushydrogel. Right: MSCs in a PEGDA hydrogel transduced with a lentiviral reporter construct, constitutively expressingtdTomato (red), and with GFP production linked to the Collagen 2 promoter. Osteoarthritis and Cartilage 2016 24, S162-S163DOI: (10.1016/j.joca.2016.01.320) Copyright © 2016 Terms and Conditions