Caught on Camera: Intermediates of Ribosome Recycling

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Caught on Camera: Intermediates of Ribosome Recycling Clarence Ling, Dmitri N. Ermolenko  Structure  Volume 24, Issue 12, Pages 2035-2036 (December 2016) DOI: 10.1016/j.str.2016.11.009 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 A Schematic Representation of the Structural Rearrangements of RRF and the Ribosome during Ribosome Recycling Ribosome recycling factor (RRF) is shown in red with domains I and II indicated. 50S subunit helix H69 and 30S subunit helix h44 are shown as light blue and green cylinders, respectively. EF-G is dark blue. (A) The arrowhead in indicates intersubunit bridge B2a formed by the contact between H69 and h44. (B) Binding of EF-G induces an interdomain movement in RRF that positions domain II of RRF closer to bridge B2a. (C) Subsequent structural rearrangements, which may be triggered by release of inorganic phosphate after GTP hydrolysis catalyzed by EF-G, result in further rotation of RRF domain to toward the tip of H69 and the dissociation of the 30S subunit, depicted as the separation of H69 and h44. Structure 2016 24, 2035-2036DOI: (10.1016/j.str.2016.11.009) Copyright © 2016 Elsevier Ltd Terms and Conditions