The calpain system and diabetes Muthuraman Pandurangan, Inho Hwang, Chinzorio Orhirbat, Yang Jieun, Soo-Hyun Cho  Pathophysiology  Volume 21, Issue 2, Pages 161-167 (June 2014) DOI: 10.1016/j.pathophys.2014.01.003 Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 General structural organization of calpains. Catalytic subunits have four domains (DI–DIV) and regulatory subunits have two domains (DV and DVI), respectively. DI is autolysed during calpain activation by calcium. DII is the conserved protease domain, which is sub-divided into the subdomains such as IIa and IIb, which form a signal domain during calcium binding. DIII consisting C2 domains, which is participates in structural changes during calcium binding. The carboxy-terminal domains DIV and DVI contain five EF hands and the fifth EF hand involves the subunits dimerization. This figure adopted from Harris et al. (2004). Pathophysiology 2014 21, 161-167DOI: (10.1016/j.pathophys.2014.01.003) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions