Imprinting disorders and assisted reproductive technology

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Presentation transcript:

Imprinting disorders and assisted reproductive technology Somjate Manipalviratn, M.D., Alan DeCherney, M.D., James Segars, M.D. Fertility and Sterility Volume 91, Issue 2, Pages 305-315 (February 2009) DOI: 10.1016/j.fertnstert.2009.01.002 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Diagram showing epigenetic alteration of imprinted gene cluster at chromosome 11p15.5 in BWS. (A) Normal. (B) BWS caused by DMR2 loss of methylation (most common etiology of BWS in children born after ART). (C) BWS caused by DMR1 gain of methylation. Fertility and Sterility 2009 91, 305-315DOI: (10.1016/j.fertnstert.2009.01.002) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Diagram showing epigenetic alteration of imprinted gene cluster at chromosome 15q11-13 in AS. (A) Normal. (B) AS caused by SNRPN DMR loss of methylation. Fertility and Sterility 2009 91, 305-315DOI: (10.1016/j.fertnstert.2009.01.002) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions