Volume 372, Issue 9634, Pages (July 2008)

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Volume 372, Issue 9634, Pages 216-223 (July 2008) Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial Prof Clive Holmes, MRCPsych, Delphine Boche, PhD, David Wilkinson, FRCPsych, Ghasem Yadegarfar, PhD, Vivienne Hopkins, RMN, Anthony Bayer, MRCP, Prof Roy W Jones, FRCP, Roger Bullock, MRCPsych, Prof Seth Love, FRCPath, James W Neal, FRCPath, Elina Zotova, BSc, Prof James AR Nicoll, FRCPath The Lancet Volume 372, Issue 9634, Pages 216-223 (July 2008) DOI: 10.1016/S0140-6736(08)61075-2 Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 1 Trial profile The Lancet 2008 372, 216-223DOI: (10.1016/S0140-6736(08)61075-2) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 2 Histological patterns of Aβ in the temporal lobe neocortex after immunisation with AN1792 An unimmunised control (top left) has a high density of plaques. Cases 1–8 are all patients who were immunised with Aβ42. Case 1 died 4 months after the first immunisation dose and showed an early stage of Aβ removal. Cases 2–8 survived 20–64 months after first immunisation dose. Case 2 did not develop anti-Aβ antibodies and showed no evidence of plaque clearance. Cases 3–6 showed an intermediate range of plaque clearance. Cases 7 and 8 showed very extensive (case 8) to nearly complete (case 7) removal of Aβ plaques throughout the cerebral cortex. All the long-term survivors (ie, cases 2–8) continued to have progressive dementia with cognitive function declining to an unrecordable level (ie, MMSE=0) before death. Scale bar=0·5 mm. The Lancet 2008 372, 216-223DOI: (10.1016/S0140-6736(08)61075-2) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 3 Mean antibody response to AN1792 and Aβ plaque removal The Lancet 2008 372, 216-223DOI: (10.1016/S0140-6736(08)61075-2) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 4 Kaplan-Meier estimates of survival time to death by treatment group The Lancet 2008 372, 216-223DOI: (10.1016/S0140-6736(08)61075-2) Copyright © 2008 Elsevier Ltd Terms and Conditions

Figure 5 Kaplan-Meier estimates of time to severe dementia by treatment group The Lancet 2008 372, 216-223DOI: (10.1016/S0140-6736(08)61075-2) Copyright © 2008 Elsevier Ltd Terms and Conditions