Interrelationships of quantitative asthma-related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness,

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Interrelationships of quantitative asthma-related phenotypes in the Epidemiological Study on the Genetics and Environment of Asthma, Bronchial Hyperresponsiveness, and Atopy Marie-Pierre Oryszczyn, BSc, Emmanuelle Bouzigon, MD, PhD, Jean Maccario, PhD, Valérie Siroux, PhD, Rachel Nadif, PhD, Anne Wright, PhD, Francine Kauffmann, MD Journal of Allergy and Clinical Immunology Volume 119, Issue 1, Pages 57-63 (January 2007) DOI: 10.1016/j.jaci.2006.09.026 Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Concordance of SPT positivity, high IgE levels, and eosinophilia in asthmatic cases according to age and sex (Venn diagrams). Journal of Allergy and Clinical Immunology 2007 119, 57-63DOI: (10.1016/j.jaci.2006.09.026) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Associations of total IgE levels, eosinophil counts, and FEV1/H2 by age in cases and control subjects over the lifespan. Control subjects (n = 309) and patients (n = 299) are represented by open circles/thin curves and solid circles/thick curves, respectively. Cases and control subjects differed significantly for all parameters (P < .001). FEV1/H2 decrease with age among adults was significantly steeper in cases than in control subjects (P < .001). Journal of Allergy and Clinical Immunology 2007 119, 57-63DOI: (10.1016/j.jaci.2006.09.026) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Associations of total IgE levels, SPTQ scores, and FEV1 with eosinophil tertiles according to asthma in children and adults. Numbers of subjects in each group are shown below the bars. ∗P ≤ .01; ‡P ≤ .05. Journal of Allergy and Clinical Immunology 2007 119, 57-63DOI: (10.1016/j.jaci.2006.09.026) Copyright © 2007 American Academy of Allergy, Asthma & Immunology Terms and Conditions