F. Verrey, P. Fakitsas, G. Adam, O. Staub Kidney International

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Presentation transcript:

Early transcriptional control of ENaC (de)ubiquitylation by aldosterone F. Verrey, P. Fakitsas, G. Adam, O. Staub Kidney International Volume 73, Issue 6, Pages 691-696 (March 2008) DOI: 10.1038/sj.ki.5002737 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Model for the early transcriptional action of aldosterone on ENaC function. The ubiquitin ligase Nedd4-2 that tonically inhibits ENaC surface expression is highlighted in red, and red dashed arrows indicate pathways downregulating ENaC that are antagonized by aldosterone. Blue boxes represent the regulatory proteins implicated in the early aldosterone action that are rapidly induced via activated MR. The blue lines terminated by a dash indicate at what level these regulatory proteins interfere with ENaC inhibition. Kidney International 2008 73, 691-696DOI: (10.1038/sj.ki.5002737) Copyright © 2008 International Society of Nephrology Terms and Conditions