Steroid-Refractory Acute GVHD: Lack of Long-Term Improved Survival Using New Generation Anticytokine Treatment Aliénor Xhaard, Vanderson Rocha, Benjamin.

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Steroid-Refractory Acute GVHD: Lack of Long-Term Improved Survival Using New Generation Anticytokine Treatment Aliénor Xhaard, Vanderson Rocha, Benjamin Bueno, Régis Peffault de Latour, Julien Lenglet, Anna Petropoulou, Paula Rodriguez- Otero, Patricia Ribaud, Raphael Porcher, Gérard Socié, Marie Robin Biology of Blood and Marrow Transplantation Volume 18, Issue 3, Pages 406-413 (March 2012) DOI: 10.1016/j.bbmt.2011.06.012 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Cumulative incidence of complete remission and competing events. Figure 1 displays the cumulative incidence of CR after second-line treatment, with progression and death considered as competing events. At each time are depicted the estimated probability of CR (lower curve), the estimated probability of progression or death (from the top to the gray curve) and the estimated probability of still being in PR/SD (between both curves). CR indicates complete response; PR, partial response; SD, stable disease; PD, progression of GVHD. Biology of Blood and Marrow Transplantation 2012 18, 406-413DOI: (10.1016/j.bbmt.2011.06.012) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 OS (A) and OS according to complete response (B) or to second-line therapy with adjustment (C). Figure 2 displays the OS (A), the OS according to complete response to second-line treatment (B), and the adjusted survival (C) according to second-line treatment. Dashed lines represent point-wise 95% confidence intervals, and ticks denote censored observations. Biology of Blood and Marrow Transplantation 2012 18, 406-413DOI: (10.1016/j.bbmt.2011.06.012) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Probability of viral (A), bacterial (B), and fungal (C) infections according to second-line therapy. Figure 3 displays the probabilities of viral (A), bacterial (B), and fungal (C) infections at 24 months after second-line treatment initiation, according to the second-line treatment received. Biology of Blood and Marrow Transplantation 2012 18, 406-413DOI: (10.1016/j.bbmt.2011.06.012) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions