Putative processing of the astrovirus nonstructural proteins expressed from ORF1a and ORF1b. Putative processing of the astrovirus nonstructural proteins.

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Putative processing of the astrovirus nonstructural proteins expressed from ORF1a and ORF1b. Putative processing of the astrovirus nonstructural proteins expressed from ORF1a and ORF1b. HEL, putative helicase domain; CC, coiled-coil domain; TM, transmembrane domain; PRO, protease domain; VPg, viral protein genome-linked coding region; HVR, hypervariable region; RdRp, RNA-dependent RNA polymerase motif; P, posttranslational phosphorylation. Triangles depict proteolytic cleavage sites described in the literature (75, 77, 78, 80). Albert Bosch et al. Clin. Microbiol. Rev. 2014; doi:10.1128/CMR.00013-14