Elaine Ku, Joel D. Kopple, Kirsten L. Johansen, Charles E

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Longitudinal Weight Change During CKD Progression and Its Association With Subsequent Mortality Elaine Ku, Joel D. Kopple, Kirsten L. Johansen, Charles E. McCulloch, Alan S. Go, Dawei Xie, Feng Lin, L. Lee Hamm, Jiang He, John W. Kusek, Sankar D. Navaneethan, Ana C. Ricardo, Hernan Rincon-Choles, Miroslaw Smogorzewski, Chi-yuan Hsu Lawrence J. Appel, Harold I. Feldman, James P. Lash, Akinlolu Ojo, Mahboob Rahman, Raymond R. Townsend Elaine Ku, Joel D. Kopple, Kirsten L. Johansen, Charles E. McCulloch, Alan S. Go, Dawei Xie, Feng Lin, L. Lee Hamm, Jiang He, John W. Kusek, Sankar D. Navaneethan, Ana C. Ricardo, Hernan Rincon-Choles, Miroslaw Smogorzewski, Chi-yuan Hsu Lawrence J. Appel, Harold I. Feldman, James P. Lash, Akinlolu Ojo, Mahboob Rahman, Raymond R. Townsend American Journal of Kidney Diseases Volume 71, Issue 5, Pages 657-665 (May 2018) DOI: 10.1053/j.ajkd.2017.09.015 Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Derivation of the Chronic Renal Insufficiency Cohort (CRIC) for weight trajectory and death analysis. ∗Dialysis includes peritoneal dialysis and hemodialysis. Abbreviations: BMI, body mass index; eGFR, estimated glomerular filtration rate. American Journal of Kidney Diseases 2018 71, 657-665DOI: (10.1053/j.ajkd.2017.09.015) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Repeated measurements of weight and body mass index (BMI) with advancing chronic kidney disease. The figure shows repeated measurements of weight (or BMI) with repeated measurements of eGFR among the same participants over time. In general, weight (or BMI) is noted to be stable until eGFR of ∼35 mL/min/1.73 m2, when steeper declines in weight (or BMI) are noted to occur. (A) Longitudinal repeated measurements of weight with repeated measurements of estimated glomerular filtration rate (eGFR) by cystatin C (CYS) in the Chronic Renal Insufficiency Cohort (CRIC). (B) Longitudinal repeated measurements of BMI with repeated measurements of eGFR CYS in CRIC. (C) Longitudinal repeated measurements of weight with repeated measurements of eGFR by creatinine (CRE) in CRIC. (D) Longitudinal repeated measurements of BMI with repeated measurements of eGFR CRE in CRIC. (E) Longitudinal repeated measurements of weight with repeated measurements of eGFR CRE in the African American Study of Kidney Disease and Hypertension (AASK). (F) Longitudinal repeated measurements of BMI with repeated measurements of eGFR CRE in AASK. Abbreviation: CKD-EPI, CKD Epidemiology Collaboration. Dotted line indicates 95% confidence interval. All eGFR is in mL/min/1.73 m2. American Journal of Kidney Diseases 2018 71, 657-665DOI: (10.1053/j.ajkd.2017.09.015) Copyright © 2017 National Kidney Foundation, Inc. Terms and Conditions