Colonic H+-K+-ATPase is induced and mediates increased HCO3− reabsorption in inner medullary collecting duct in potassium depletion Suguru Nakamura,

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Colonic H+-K+-ATPase is induced and mediates increased HCO3− reabsorption in inner medullary collecting duct in potassium depletion Suguru Nakamura, Hassane Amlal, John H. Galla, Manoocher Soleimani Kidney International Volume 54, Issue 4, Pages 1233-1239 (October 1998) DOI: 10.1046/j.1523-1755.1998.00105.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Gastric H-K-ATPase (gHKA) Northern hybridizations in renal papilla of normal (C) or potassium depleted rats. Upper panel, gHKA Northern hybridization; lower panel, 28S rRNA Northern hybridization. Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Colon H-K-ATPase (cHKA) Northern hybridizations in renal papilla of normal (C) or potassium depleted rats. Upper panel, cHKA Northern hybridization; lower panel, 28S rRNA Northern hybridization. Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 (A) Effect of 10 μm Schering 28080 (SCH) or 1mm ouabain (OUA) in perfusate on JtCO2 in normal rats. Each bar represents mean ± se. Each bar represents the mean ± se for 5 control, 5 ouabain or 5 SCH separate experiments. Tubule lengths were 0.92 ± 0.05mm and perfusion rates 1.11 ± 0.04 nl/min. The order of perfusion was random and that the order shown in the Figures is the final tabulation of the data once unblinded. *Significant difference versus control. (B) Time dependency of JtCO2 in terminal IMCD. Effect of time on JtCO2 in terminal IMCD was studied by measuring net HCO3− reabsorption in terminal IMCD for three consecutive 30minutes collections in the absence of any inhibitors in perfusates. Tubule lengths were 1.13 ± 0.20mm and perfusion rates were 1.39 ± 0.12 nl/min. Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 JtCO2 in normal or potassium depleted rats. There were 5 animals in the normal group and 4 animals in the potassium depleted group. For normal and potassium depleted rats the tubule lengths were respectively 0.92 ± 0.05 and 0.74 ± 0.04mm, and the perfusion rates were respectively 1.11 ± 0.04 and 1.26 ± 0.05 nl/min. Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Effect of 10 μm SCH or 1mm ouabain in perfusate on JtCO2 in potassium depleted rats. Each bar represents mean ± se for 6 (control), 6 (ouabain) or 6 (SCH) separate experiments. Tubule lengths were 0.75 ± 0.08mm and perfusion rates 1.31 ± 0.06 nl/min. The order of perususion was random (see legend to Figure 3). *Significant difference versus control. Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 6 Effect of SCH plus ouabain on JtCO2 in potassium depleted rats. Each bar represents mean ± se for 6 separate experiments. Tubule lengths were 0.88 ± 0.13mm and perfusion rates 1.28 ± 0.06 nl/min. The order of perususion was random (see legend to Figure 3). *Significant difference versus control. Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 1233-1239DOI: (10. 1046/j. 1523-1755 Kidney International 1998 54, 1233-1239DOI: (10.1046/j.1523-1755.1998.00105.x) Copyright © 1998 International Society of Nephrology Terms and Conditions