H. Zhang, M. D. , Ph. D. , K. W. Marshall, M. D. , Ph. D. , F. R. C. S

Slides:

Advertisements

Similar presentations

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Ms L. Torres, B.A., Dr D.D. Dunlop, Ph.D., Dr C.

Advertisements

H. Zhang, M. D. , Ph. D. , K. W. Marshall, M. D. , Ph. D. , F. R. C. S

The disease modifying osteoarthritis drug diacerein is able to antagonize pro inflammatory state of chondrocytes under mild mechanical stimuli B. Steinecker-Frohnwieser,

IGF-1 does not moderate the time-dependent transcriptional patterns of key homeostatic genes induced by sustained compression of bovine cartilage C.A.

D. N. Clements, B. Sc. , B. V. Sc. , S. D. Carter, Ph. D. , J. F

The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-α and MMP13 S.W. Jones, Ph.D., G.

Top-Cited Articles in Rehabilitation

Effect of glucosamine and its peptidyl-derivative on the production of extracellular matrix components by human primary chondrocytes D. Stoppoloni, L.

C.B. Chang, S.A. Han, E.M. Kim, S. Lee, S.C. Seong, M.C. Lee

Agonists of peroxisome proliferators-activated receptors (PPAR) α, β/δ or γ reduce transforming growth factor (TGF)-β-induced proteoglycans' production.

C.B. Chang, S.A. Han, E.M. Kim, S. Lee, S.C. Seong, M.C. Lee

Synergistic effect of IGF-1 and OP-1 on matrix formation by normal and OA chondrocytes cultured in alginate beads S. Chubinskaya, Ph.D., A. Hakimiyan,

Gene expression profiling for confirmation of effects of DNA polymeric molecules on in vitro arthritis model H.-J. Kim, A. Baek, M. Kim, S.-R. Cho Osteoarthritis.

Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms M. Hall, S. Doherty,

Toward scaffold-based meniscus repair: effect of human serum, hyaluronic acid and TGF-ß3 on cell recruitment and re-differentiation U. Freymann, M. Endres,

C. Sanchez, Ph. D. , O. Gabay, Ph. D. , C. Salvat, B. Sc. , Y. E

Expression and regulation of Toll-like receptor 2 by IL-1β and fibronectin fragments in human articular chondrocytes S.-L. Su, M.S., C.-D. Tsai, Ph.D.,

Subsets of symptomatic hand osteoarthritis in community-dwelling older adults in the United Kingdom: prevalence, inter-relationships, risk factor profiles.

Osteoblasts from the sclerotic subchondral bone downregulate aggrecan but upregulate metalloproteinases expression by chondrocytes. This effect is mimicked.

C-reactive protein, metabolic syndrome and incidence of severe hip and knee osteoarthritis. A population-based cohort study G. Engström, M.D., Ph.D.,

E. Rodriguez, B.Sc., Dr. P. Roughley, Ph.D.

Health-related quality of life and costs in patients with osteoarthritis on waiting list for total knee replacement M. Núñez, Ph.D., E. Núñez, Ph.D.,

Y. Kodama, T. Furumatsu, M. Fujii, T. Hino

Efficacy and safety of intraarticular hyaluronic acid in the treatment of hip osteoarthritis: a systematic review J.C. Fernández López, M.D., Ph.D.,

B. Slatkowsky-Christensen, M. D. , T. K. Kvien, M. D. , Ph. D. , N

H Jo, M. D. , J. S Park, Ph. D. , E. M Kim, M. S. , M. Y Jung, Ph. D

Photo-crosslinked alginate hydrogels support enhanced matrix accumulation by nucleus pulposus cells in vivo A.I. Chou, S.O. Akintoye, S.B. Nicoll Osteoarthritis.

Characterization of pro-apoptotic and matrix-degradative gene expression following induction of osteoarthritis in mature and aged rabbits Dr. C.M. Robertson,

Dr. M. C. Honorati, Ph. D. , S. Neri, Ph. D. , L. Cattini, B. Sc. , A

Enhancing and maintaining chondrogenesis of synovial fibroblasts by cartilage extracellular matrix protein matrilins M. Pei, M.D., Ph.D., J. Luo, M.D.,

S. Sonne-Holm, M.D., Dr. Sci., S. Jacobsen, M.D.

Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic.

N.D. Miljkovic, M.D., Ph.D., G.M. Cooper, Ph.D., K.G. Marra, Ph.D.

T. Kurth, M. Sc. , E. Hedbom, Ph. D. , N. Shintani, Ph. D. , M

Low rate of total hip replacement as reflected by a low prevalence of hip osteoarthritis in South Korea H.A. Kim, M.D., Ph.D., S.H. Koh, M.D., Ph.D.,

Z. Lin, M. B. , N. J. Pavlos, B. Sc. (Hons. ), Ph. D. , M. A. Cake, B

Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFβ2 and FGF2 Y.M. Jenniskens, M.Sc., W. Koevoet, B.Sc., A.C.W. de.

Growth characterization of neo porcine cartilage pellets and their use in an interactive culture model Carsten Lübke, Ph.D., Jochen Ringe, M.Sc., Veit.

M.D. Westby, D.A. Marshall, C.A. Jones Osteoarthritis and Cartilage

Measurement properties of the WOMAC LK 3.1 pain scale

Validation of a self-report instrument for assessment of hallux valgus

Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies T.

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (Fabp-4) alleviates osteoarthritis induced by a very high fat diet in mouse

Characterization of proteoglycan production and processing by chondrocytes and BMSCs in tissue engineered constructs J.T. Connelly, Ph.D., C.G. Wilson,

A Role for Estrogen Receptor-α and Estrogen Receptor-β in Collagen Biosynthesis in Mouse Skin Margaret Markiewicz, Sergey Znoyko, Lukasz Stawski, Angela.

L. De Franceschi, Ph. D. , L. Roseti, Ph. D. , G. Desando, Ph. D. , A

S. P Grogan, Ph. D. , F Rieser, B. Sc

Structure of pericellular matrix around agarose-embedded chondrocytes

Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1β- stimulated chondrocytes – study in hypoxic alginate bead cultures

Comparative analysis of gene expression profiles between the normal human cartilage and the one with endemic osteoarthritis W.Z. Wang, M.D., Ph.D., X.

Changes in chondrocyte primary cilia structure and function are associated with altered mechanoregulation in Alkaptonuria S.D. Thorpe, S. Gambassi, R.

N. Takahashi, Ph. D. , K. Rieneck, M. D. , P. M. van der Kraan, Ph. D

Erratum to “MMP and non-MMP-mediated release of aggrecan and its fragments from articular cartilage: a comparative study of three different aggrecan and.

The development of a short measure of physical function for knee OA KOOS-Physical Function Shortform (KOOS-PS) – an OARSI/OMERACT initiative A.V. Perruccio,

L Kalichman, B. P. T. , E Kobyliansky, Ph. D. , I Malkin, Ph. D

A single application of cyclic loading can accelerate matrix deposition and enhance the properties of tissue-engineered cartilage Dr S.D. Waldman, Ph.D.,

Gene expression profiling of chondrocytes from a porcine impact injury model M.S. Ashwell, Ph.D., A.T. O'Nan, M.S., M.G. Gonda, Ph.D., P.L. Mente, Ph.D.

Novel juvenile factors for cartilage regeneration

B. Zielinska, M. Killian, M. Kadmiel, M. Nelsen, T.L. Haut Donahue

R. H. J. Das, M. Sc. , H. Jahr, Ph. D. , J. A. N. Verhaar, M. D. , Ph

F. Zhang, Ph. D. , G. Zhai, Ph. D. , B. S. Kato, Ph. D. , D. J

The cleavage of biglycan by aggrecanases

The detached osteochondral fragment as a source of cells for autologous chondrocyte implantation (ACI) in the ankle joint S. Giannini, M.D., R. Buda,

Patients' thromboembolic potential after carotid endarterectomy is related to the platelets' sensitivity to adenosine diphosphate Paul D Hayes, FRCS,

Demineralized bone alters expression of Wnt network components during chondroinduction of post-natal fibroblasts Karen E. Yates, Ph.D Osteoarthritis.

Erratum to “Effect of hyaluronic acid (MW 500–730kDa) on proteoglycan and nitric oxide production in human osteoarthritic chondrocyte cultures exposed.

Effect of hyaluronic acid (MW 500–730kDa) on proteoglycan and nitric oxide production in human osteoarthritic chondrocyte cultures exposed to hydrostatic.

K. W. Marshall, M. D. , Ph. D. , F. R. C. S. (C), H. Zhang, M. D. , Ph

One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression M.A. Deberg,

Effects of physical stimulation with electromagnetic field and insulin growth factor-I treatment on proteoglycan synthesis of bovine articular cartilage

Presentation transcript:

Profiling genes expressed in human fetal cartilage using 13,155 expressed sequence tags H. Zhang, M.D., Ph.D., K.W. Marshall, M.D., Ph.D., F.R.C.S. (C), H. Tang, M.Sc., D.M. Hwang, M.D., Ph.D., M. Lee, B.Sc., C.C. Liew, Ph.D. Osteoarthritis and Cartilage Volume 11, Issue 5, Pages 309-319 (May 2003) DOI: 10.1016/S1063-4584(03)00032-3

Fig. 1 Relative expression levels of seven types of ECM proteins in human fetal cartilage. EST numbers matched to each type of ECM were summed. EST frequency was then calculated by dividing the EST copy number of each ECM into the total number of ECM ESTs (n=1056). COL, collagens; PG, proteoglycans; MATN1, matrilin 1; SPARC, secreted protein, acidic and rich in cysteine (osteonectin); CRTL1, cartilage link protein 1; FN, fibronectin. Osteoarthritis and Cartilage 2003 11, 309-319DOI: (10.1016/S1063-4584(03)00032-3)

Fig. 2 Relative expression levels of nine collagen genes in human fetal cartilage. Relative EST frequency level was calculated by dividing the EST copy number of each collagen gene into the total number of collagen ESTs (n=723). Osteoarthritis and Cartilage 2003 11, 309-319DOI: (10.1016/S1063-4584(03)00032-3)

Fig. 3 Relative expression levels of six proteoglycan genes in human fetal cartilage. Relative EST frequency level was calculated by dividing the EST copy number of each proteoglycan gene into the total number of proteoglycan ESTs (n=92). GPC3, glypican 3; DCN, decorin; AGG, aggrecan; PG4, proteoglycan 4; LUM, lumican; SDC2, syndecan 2; FMOD, fibromodulin. Osteoarthritis and Cartilage 2003 11, 309-319DOI: (10.1016/S1063-4584(03)00032-3)