Antigen-primed splenic CD8+ T cells impede the development of oral antigen–induced allergic diarrhea Akiko Yamada, MD, Yusei Ohshima, MD, PhD, Motoko.

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Presentation transcript:

Antigen-primed splenic CD8+ T cells impede the development of oral antigen–induced allergic diarrhea Akiko Yamada, MD, Yusei Ohshima, MD, PhD, Motoko Yasutomi, MD, PhD, Kazumasa Ogura, MD, Shuko Tokuriki, MD, PhD, Hironobu Naiki, MD, PhD, Mitsufumi Mayumi, MD, PhD Journal of Allergy and Clinical Immunology Volume 123, Issue 4, Pages 889-894 (April 2009) DOI: 10.1016/j.jaci.2008.12.1115 Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Diarrhea (A) and hypothermia (B) occurrences in wild-type and TCR-tg mice after ovalbumin challenge (n = 12). Concentrations of serum ovalbumin-specific IgE (C), IgG1(D), and IgG2a(E) for wild-type and TCR-tg mice were measured preovalbumin and postovalbumin challenge. The frequency of TCRαβ+CD8+ T cells among lymphocytes (F). Results are representative of 3 experiments. ∗P < .01; ∗∗P < .005. Ag, Antigen; Au, arbitrary antibody unit. Journal of Allergy and Clinical Immunology 2009 123, 889-894DOI: (10.1016/j.jaci.2008.12.1115) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Diarrhea (A) and hypothermia (B) occurrences in TCR-tg mice with or without transferred CD8+ T cells (n = 12). The jejunum of nontransferred (C) and primed CD8+ T cell–transferred (D) TCR-tg mice. Numbers of eosinophils (E) and mast cells (F) in gastrointestinal mucosa in nontransferred and primed CD8+ T-cell–transferred TCR-tg mice. G, mmcp-1 mRNA expression in jejunums of control without antigen (Ag) challenge, nontransferred, and primed CD8+ T-cell–transferred TCR-tg mice. Results are representative of 3 experiments. ∗P < .05; ∗∗P < .001. hpf, High-power field. Journal of Allergy and Clinical Immunology 2009 123, 889-894DOI: (10.1016/j.jaci.2008.12.1115) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Serum ovalbumin-specific IgE (A), IgG1(B), and IgG2a(C) concentrations of nontransferred (closed bars), ovalbumin-primed CD8+ T cell–transferred (open bars), and nonprimed CD8+ T cell–transferred (gray bars) TCR-tg were measured at preovalbumin and postovalbumin challenges. Results are representative of 3 experiments. Au, Arbitrary antibody unit. Journal of Allergy and Clinical Immunology 2009 123, 889-894DOI: (10.1016/j.jaci.2008.12.1115) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Cytokine mRNA expression in the jejunum (A) and MLNs (B) from control nontransferred, non–antigen-challenged TCR-tg mice (hatched bars), and nontransferred (closed bars), and primed CD8+ T-cell–transferred (open bars) TCR-tg mice after oral antigen challenge. Results are representative of 3 experiments. ∗P < .05. Journal of Allergy and Clinical Immunology 2009 123, 889-894DOI: (10.1016/j.jaci.2008.12.1115) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 In vitro ovalbumin (OVA)–specific IL-4 (A), IFN-γ (B), and IL-10 (C) production by MLN mononuclear cells purified from nontransferred (closed bars), primed CD8+ T-cell–transferred (open bars), and nonprimed CD8+ T-cell–transferred (gray bars) TCR-tg mice after oral antigen challenge. Results are representative of 3 experiments. ∗P < .05. Journal of Allergy and Clinical Immunology 2009 123, 889-894DOI: (10.1016/j.jaci.2008.12.1115) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 6 Diarrhea (A) and hypothermia (B) occurrences in TCR-tg mice transferred with or without ovalbumin-primed wild or IL-10 knockout (KO) CD8+ T cells (n = 12). IL-4 (C) and mmcp-1 (D) mRNA expression in jejunums from nonchallenged control, nontransferred, and primed wild or IL-10KO CD8+ T-cell–transferred TCR-tg mice. Results are representative of 3 experiments. ∗P < .05. Ag, Antigen. Journal of Allergy and Clinical Immunology 2009 123, 889-894DOI: (10.1016/j.jaci.2008.12.1115) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions