Dietary Fat Inflames CD4+ T Cell Memory in Obesity

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Dietary Fat Inflames CD4+ T Cell Memory in Obesity Nicole M. Chapman, Hongbo Chi Cell Metabolism Volume 25, Issue 3, Pages 490-492 (March 2017) DOI: 10.1016/j.cmet.2017.02.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Metabolic Stress in Obesity Induces Effector-Memory CD4+ T Cell Responses via the PI3K/Akt Pathway Despite reducing dendritic cell (DC) activation, high-fat diets (HFDs) provide saturated fatty acids (SFAs) that increase T cell membrane fluidity, subsequently augmenting T cell antigen receptor (TCR) clustering and signaling via the PI3K/Akt pathway upon encountering the cognate peptide-major histocompatibility complex (pMHC) molecule. Concurrently, fatty acid oxidation (FAO) of SFAs like palmitate is increased. These alterations promote the acquisition of an effector-memory T (TEM) cell phenotype that allows for trafficking to non-lymphoid tissues and inflammatory sites. Moreover, the downregulation of Sell (which encodes for CD62L) and Ccr7 (which encodes for CCR7) limits TEM cell trafficking to lymphoid tissues. Cell Metabolism 2017 25, 490-492DOI: (10.1016/j.cmet.2017.02.012) Copyright © 2017 Elsevier Inc. Terms and Conditions