Race and Melanocortin 1 Receptor Polymorphism R163Q Are Associated with Post- Burn Hypertrophic Scarring: A Prospective Cohort Study  Ravi F. Sood, Anne M. Hocking, Lara A. Muffley, Maricar Ga, Shari Honari, Alexander P. Reiner, Ali Rowhani-Rahbar, Nicole S. Gibran  Journal of Investigative Dermatology  Volume 135, Issue 10, Pages 2394-2401 (October 2015) DOI: 10.1038/jid.2015.197 Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Location and prevalence of the MC1R variants studied. (a) The eight single-nucleotide polymorphisms (SNPs) considered in this study are named according to their corresponding amino-acid substitutions, denoted by single-letter amino-acid codes and residue number, as indicated in this cartoon of the MC1R amino–acid sequence. Boxes indicate the seven transmembrane domains. (b) Overall and race-specific frequencies of seven MC1R SNPs are illustrated in a heat map to highlight variations in SNP frequencies across racial groups. The numbers of subjects in the racial subgroups do not sum up to 425 because of missing or unknown race for 12 subjects. MAF, minor allele frequency. The diagram was modified from Ringholm et al. (2004) with permission. Journal of Investigative Dermatology 2015 135, 2394-2401DOI: (10.1038/jid.2015.197) Copyright © 2015 The Society for Investigative Dermatology, Inc Terms and Conditions