HDAC4 blocks autophagy to trigger podocyte injury: non-epigenetic action in diabetic nephropathy  Qingqing Wei, Zheng Dong  Kidney International  Volume 86, Issue 4, Pages 666-668 (October 2014) DOI: 10.1038/ki.2014.142 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Schematic diagram of HDAC4–STAT1 pathway in podocyte injury. HDAC4 interacts with and deacetylates STAT1 to promote the phosphorylation and activation of STAT1, which then translocates into the nucleus to induce gene expression, leading to the induction of inflammation and apoptosis and the suppression of autophagy. Kidney International 2014 86, 666-668DOI: (10.1038/ki.2014.142) Copyright © 2014 International Society of Nephrology Terms and Conditions