Correlation of higher antibody levels to pneumococcal proteins with protection from pneumococcal acute otitis media but not protection from nasopharyngeal colonization in young children  Q. Xu, J.R. Casey, A. Almudevar, M.E. Pichichero  Clinical Microbiology and Infection  Volume 23, Issue 7, Pages 487.e1-487.e6 (July 2017) DOI: 10.1016/j.cmi.2017.01.011 Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Mucosal antibody levels were negatively associated with possibility of future episode of Streptococcus pneumoniae acute otitis media (AOM). Nasopharyngeal wash samples were collected from healthy children at 6–24 months of age. Antibody levels were determined by quantitative ELISA and expressed as the ratios of pneumococcal specific to total IgG and total IgA and compared between children who had at least one future episode of AOM 3, 6 and 12 months later and children who did not have any AOM in entire study period. (a) Anti-PhtD IgG; (b) anti-PhtD IgA; (c) anti-PcpA IgG; (d) anti-PcpA IgA; (e) anti-PlyD1 IgG; (f) anti-PlyD1 IgA. Clinical Microbiology and Infection 2017 23, 487.e1-487.e6DOI: (10.1016/j.cmi.2017.01.011) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Mucosal antibody levels were not associated with prevention of future Streptococcus pneumoniae colonization. Nasopharyngeal (NP) wash samples were collected from healthy children at 6–24 months of age. Antibody levels were determined by quantitative ELISA, expressed as the ratios of pneumococcal specific to total IgG and total IgA and compared between children who had future S. pneumoniae colonization and children who did not have future S. pneumoniae colonization 3 and 6 months later. Lines represent GM with 95% CI. (a) 3-month IgG; (b) 3-month IgA; (c) 6-month IgG; (d) 6-month IgA. Clinical Microbiology and Infection 2017 23, 487.e1-487.e6DOI: (10.1016/j.cmi.2017.01.011) Copyright © 2017 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions