Involvement of interleukin-8 in dialysis-related arthritis

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Involvement of interleukin-8 in dialysis-related arthritis Fumio Takayama, Takashi Miyazaki, Isao Aoyama, Saori Tsukushi, Motoyoshi Sato, Chikao Yamazaki, Kaoru Shimokata, Toshimitsu Niwa Kidney International Volume 53, Issue 4, Pages 1007-1013 (April 1998) DOI: 10.1111/j.1523-1755.1998.00819.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Concentrations of interleukin (IL)-8 in joint fluids of patients with dialysis-related arthritis (DRA), rheumatoid arthritis (RA) and osteoarthritis (OA). IL-8 levels in DRA and RA were markedly increased compared with OA. Data are expressed as mean ±SE (N = 8 for OA, N = 6 for DRA and N = 9 for RA).*P < 0.05 and **P < 0.01 vs. OA. Kidney International 1998 53, 1007-1013DOI: (10.1111/j.1523-1755.1998.00819.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Time course of leukocyte infiltration in joint fluids induced by intra-articular injection of IL-8. Symbols are: () IL-8; (––) IL-8 + IM-F; (–·–) saline controls. Leukocyte infiltration occurred with maximal accumulation 4 hours after injection of IL-8 (0.5 μg). The oral administration of indometacin farnesil (IM-F) reduced leukocyte infiltration into the joint space in the IL-8-induced synovitis. Data are expressed as mean ±SE (N = 8 for IL-8, N = 8 for IL-8 + IM-F and N = 4 for saline). *P < 0.05 and **P < 0.01 vs. IL-8. Kidney International 1998 53, 1007-1013DOI: (10.1111/j.1523-1755.1998.00819.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Light microscopy of the synovial tissues obtained 4 hours after injection of interleukin (IL)-8 with or without oral administration of indometacin farnesil (hematoxylin and eosin stain, ×200). (A) Synovial tissue after intra-articular injection of IL-8, showing infiltration of a large number of neutrophils on the superficial layers of the synovium. (B) Synovial tissue after intra-articular injection of IL-8 with oral administration of indometacin farnesil, showing that neutrophil infiltration was reduced. (C) Synovial tissue after intra-articular injection of endotoxin-free saline, showing normal appearance. Kidney International 1998 53, 1007-1013DOI: (10.1111/j.1523-1755.1998.00819.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 4 Effect of dexamethasone (DEX) on tumor necrosis factor alpha (TNF-α)-stimulated expression of interleukin (IL)-8 mRNA. Human synovial cells were incubated with dexamethasone for 1 hour, followed by the addition of TNF-α (0.5 ng/ml) and further incubation for 6 hours. (A) Autoradiograph of a Northern blot. (B) Densitometric analysis of the autoradiographs from two separate experiments. The amount of IL-8 mRNA was corrected with that of GAPDH mRNA (ANOVA P < 0.01). *P < 0.05 and **P < 0.01 vs. TNF-α (0.5 ng/nl) and DEX (0 M). Kidney International 1998 53, 1007-1013DOI: (10.1111/j.1523-1755.1998.00819.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 5 Effect of dexamethasone (DEX) on tumor necrosis factor-alpha (TNF-α)-stimulated production of interleukin (IL)-8. Human synovial cells were incubated with 10-7M dexamethasone for 1 hour, followed by addition of TNF-α (0.5 ng/ml) and further incubation for 24 hours. *P < 0.05 vs. TNF, by ANOVA. Kidney International 1998 53, 1007-1013DOI: (10.1111/j.1523-1755.1998.00819.x) Copyright © 1998 International Society of Nephrology Terms and Conditions