Guarding against Collateral Damage during Chromatin Transactions

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Presentation transcript:

Guarding against Collateral Damage during Chromatin Transactions Matthias Altmeyer, Jiri Lukas Cell Volume 153, Issue 7, Pages 1431-1434 (June 2013) DOI: 10.1016/j.cell.2013.05.044 Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 1 Mechanisms Guarding against Unrestrained Chromatin Transactions (A) Chromatin ubiquitylation in response to DNA damage. (B) Histone phosphorylation in response to DNA damage. (C) Histone methylation and acetylation for transcriptional activation. (D) RNA polymerase II occupancy and transcription of transposable elements and flanking genes. (E) DNA end resection in mammalian cells. (F) Cell-cycle checkpoint duration in response to DNA breaks. DUBs, deubiquitylating enzymes; Ub, ubiquitin; PPs, protein phosphatases; TE, transposable elements. Cell 2013 153, 1431-1434DOI: (10.1016/j.cell.2013.05.044) Copyright © 2013 Elsevier Inc. Terms and Conditions

Figure 2 Mechanisms to Reinforce and Restrain Chromatin Transactions Balance Benefit and Risk As in Figure 1, initiating and reinforcing activities are highlighted in blue, and limiting activities are marked in purple. Cell 2013 153, 1431-1434DOI: (10.1016/j.cell.2013.05.044) Copyright © 2013 Elsevier Inc. Terms and Conditions