Multiple injections of platelet rich plasma releasate reduce pain and synovial thickening in a mice osteoarthritis model S. Khatab, G.M. van Buul, P.K.

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Multiple injections of platelet rich plasma releasate reduce pain and synovial thickening in a mice osteoarthritis model S. Khatab, G.M. van Buul, P.K. Bos, J.A. Verhaar, G.J. van Osch Osteoarthritis and Cartilage Volume 25, Pages S10-S11 (April 2017) DOI: 10.1016/j.joca.2017.02.034 Copyright © 2017 Terms and Conditions

Fig. 1 Weight distributed on the affected limb in time in mice with collagenase-induced osteoarthritis treated with PRP releasate. In red the PRP releasate group versus in back the saline group. Treatment started at day 0, 7 days after the first collagenase injection; the blue arrows depict the time of injection of PRP releasate or saline (day 0, 2 and 4). Mean + SEM of 11 mice per group per time point are presented. * = p < 0.05. Osteoarthritis and Cartilage 2017 25, S10-S11DOI: (10.1016/j.joca.2017.02.034) Copyright © 2017 Terms and Conditions

Fig. 2 The average synovial thickness at day 5 and day 21 after treatment with PRP releasate or saline and as a control healthy contralateral knees. Every circle represents a knee from the saline group and every cube represents a knee from the PRPr group. Healthy knees are represented by triangles. Bars represent the means of each group. Day 5, n = 7 mice per group. Day 21, n = 11 mice per group. * = p < 0.05. Osteoarthritis and Cartilage 2017 25, S10-S11DOI: (10.1016/j.joca.2017.02.034) Copyright © 2017 Terms and Conditions

Fig. 3 Ranking based on the presence of iNOS and CD206 macrophages in the synovial membrane of mice knees. The presence of iNOS and CD206 positive macrophages at day 5 after start of treatment in panel A and B. And the presence of both macrophage markers at day 21 after start of treatment in panel C and D. Every circle represents a knee from the saline group and every cube represents a knee from the PRPr group. Healthy knees are represented by triangles. Bars represents the median of each group. Day 5, n = 7 mice per group. Day 21. n = 11 mice per group. *= p < 0.05. Osteoarthritis and Cartilage 2017 25, S10-S11DOI: (10.1016/j.joca.2017.02.034) Copyright © 2017 Terms and Conditions