Relevance of imaging in anti nerve growth factor inhibitor (aNGF) studies with a focus on eligibility and on-study safety – A pictorial overview F.W.

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Relevance of imaging in anti nerve growth factor inhibitor (aNGF) studies with a focus on eligibility and on-study safety – A pictorial overview F.W. Roemer, C. Miller, K. Hoover, C. Hayes, C. West, M. Brown, R. Clemmer, A. Guermazi Osteoarthritis and Cartilage Volume 23, Pages A359-A360 (April 2015) DOI: 10.1016/j.joca.2015.02.662 Copyright © 2015 Terms and Conditions

Fig 1A Baseline radiograph shows a normal medial and lateral joint space width. Osteoarthritis and Cartilage 2015 23, A359-A360DOI: (10.1016/j.joca.2015.02.662) Copyright © 2015 Terms and Conditions

Fig1B. 6 months follow-up radiograph depicts definite medial joint space narrowing (JSN; arrows) with persistent absence of osteophytes medially consistent with RPOA. Osteoarthritis and Cartilage 2015 23, A359-A360DOI: (10.1016/j.joca.2015.02.662) Copyright © 2015 Terms and Conditions

Fig 2. Coronal T1 weighted MR image shows typical metaphyseal osteonecrosis (arrows) with central fat-like signal (asterisk). Osteoarthritis and Cartilage 2015 23, A359-A360DOI: (10.1016/j.joca.2015.02.662) Copyright © 2015 Terms and Conditions

Fig 3A Radiograph of the hip joint shows superior JSN (arrows) without relevant osteophytes present. Osteoarthritis and Cartilage 2015 23, A359-A360DOI: (10.1016/j.joca.2015.02.662) Copyright © 2015 Terms and Conditions

Fig 3B Follow up image 12 months later shows near-complete destruction of the femoral head (arrows) and subsequent migration of the femur superiorly consistent with RPOA. Osteoarthritis and Cartilage 2015 23, A359-A360DOI: (10.1016/j.joca.2015.02.662) Copyright © 2015 Terms and Conditions