A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life

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Presentation transcript:

A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life Yi Zhou, Tinglin Lu, Ting Xie Cell Metabolism Volume 14, Issue 5, Pages 571-572 (November 2011) DOI: 10.1016/j.cmet.2011.10.005 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 A Working Model Explaining How dPGC-1 Might Regulate ISC Aging and Organismal Aging as Demonstrated in the Study by Rera et al dPGC-1 overexpression in intestinal stem cells (ISC) and immediate progenitor cells enteroblasts (EB) leads to an increase in mitochondrial activity and a decrease in intracellular ROS levels throughout the intestinal epithelium. dPGC1 overexpression prevents age-related loss of intestinal homeostasis and integrity and promotes longevity in Drosophila. Cell Metabolism 2011 14, 571-572DOI: (10.1016/j.cmet.2011.10.005) Copyright © 2011 Elsevier Inc. Terms and Conditions