Effects of Methylphenidate on Fatigue and Depression: A Randomized, Double-Blind, Placebo-Controlled Trial Christopher W. Kerr, MD, PhD, Julie Drake,

Slides:

Advertisements

Similar presentations

Factors Associated With the Provision of Hospice Care for Children Lisa C. Lindley, PhD, RN, Barbara A. Mark, PhD, RN, FAAN, Shoou-Yih Daniel Lee, PhD,

Advertisements

Capturing the Costs of End-of-Life Care: Comparisons of Multiple Sclerosis, Parkinson's Disease, and Dementia Paul McCrone, PhD Journal of Pain and.

Management of Phantom Pain with a Textile, Electromagnetically-Acting Stump Liner: A Randomized, Double-Blind, Crossover Study Uwe Kern, MD, Bernd Altkemper,

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain Xiaowei.

Relieving Symptoms in Cancer: Innovative Use of Art Therapy

Chronic Pain Management in Older Adults: Special Considerations

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Pain, Demographics, and Clinical Characteristics in Persons Who Received Hospice Care in the United States Scott A. Strassels, PharmD, PhD, BCPS, David.

The Public Health Strategy for Palliative Care

Chronic Pain Management in Older Adults: Special Considerations

Why Now? Timing and Circumstances of Hastened Deaths

Analgesic and Sedative Effects of Melatonin in Temporomandibular Disorders: A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study Liliane.

Edmonton, Canada: A Regional Model of Palliative Care Development

Guided Imagery for Non-Musculoskeletal Pain: A Systematic Review of Randomized Clinical Trials Paul Posadzki, PhD, Wendy Lewandowski, PhD, APRN, BC,

Psychostimulants for the Management of Cancer-Related Fatigue: A Systematic Review and Meta-Analysis Ollie Minton, MSc, Alison Richardson, PhD, Michael.

Pilot Randomized Controlled Trial of a Patient-Controlled Cognitive-Behavioral Intervention for the Pain, Fatigue, and Sleep Disturbance Symptom Cluster.

A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced.

Relationship of Problem-Focused Coping Strategies to Changes in Quality of Life Following Treatment for Early Stage Breast Cancer Sean Ransom, MA, Paul.

David M. Simpson, MD, Lydia Estanislao, MD, Stephen J

Efficacy of Dexmethylphenidate for the Treatment of Fatigue After Cancer Chemotherapy: A Randomized Clinical Trial Elyse E. Lower, MD, Stewart Fleishman,

Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment Gillian Prue, PhD, James Allen, PhD, Jacqueline Gracey, PhD, Jane Rankin,

What Palliative Care-Related Problems Do Patients Experience at HIV Diagnosis? A Systematic Review of the Evidence Victoria M. Simms, MSc, Irene J. Higginson,

Bupropion for Control of Hot Flashes in Breast Cancer Survivors: A Prospective, Double-Blind, Randomized, Crossover, Pilot Phase II Trial Geila Ribeiro.

Use of the Cumulative Proportion of Responders Analysis Graph to Present Pain Data Over a Range of Cut-Off Points: Making Clinical Trial Data More Understandable

Caffeine as an Adjuvant Therapy to Opioids in Cancer Pain: A Randomized, Double- Blind, Placebo-Controlled Trial Sang-Yeon Suh, MD, PhD, Youn Seon Choi,

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain Xiaowei.

Capturing the Costs of End-of-Life Care: Comparisons of Multiple Sclerosis, Parkinson's Disease, and Dementia Paul McCrone, PhD Journal of Pain and.

Double-Blind, Placebo-Controlled Trial of Lamotrigine in Combination with Other Medications for Neuropathic Pain Marianne Silver, MS, David Blum, MD,

How to Measure the International Development of Palliative Care

What Can We Learn About the Spiritual Needs of Palliative Care Patients From the Research Literature? Mark Cobb, MA, Christopher Dowrick, MD, FRCGP,

David Clark, PhD, Michael Wright, PhD

Redefining Appropriate Treatment Expectations

Jodi L. Hannan, MD, Steven M. Radwany, MD, Terry Albanese, PhD

Evaluation of Methadone Absorption After Topical Administration to Hospice Patients Robert K. Sylvester, PharmD, Caroline Schauer, RN, John Thomas, MD,

A Pilot Randomized Controlled Trial of an Oral Care Intervention to Reduce Mucositis Severity in Stem Cell Transplant Patients Prisco Salvador, RN, MScN,

Barrie R. Cassileth, PhD, Andrew J. Vickers, PhD

Steven Z. Pantilat, MD, Kathleen M. Kerr, BA, J

Robert L. Jayes, MD, Robert M. Arnold, MD, Erik K. Fromme, MD

Susan C. Miller, PhD, Dan K. Kiely, MPH, MA, Joan M

The Brief Fatigue Inventory: Comparison of Data Collection Using a Novel Audio Device with Conventional Paper Questionnaire Edward Pallett, PhD, Patricia.

Emotional Disclosure Through Patient Narrative May Improve Pain and Well-Being: Results of a Randomized Controlled Trial in Patients with Cancer Pain

Psychometric Properties of Instruments Used to Measure Fatigue in Children and Adolescents With Cancer: A Systematic Review Deborah Tomlinson, MN, RN,

U.S. Hospice Benefits Journal of Pain and Symptom Management

The Spiritual Needs Assessment for Patients (SNAP): Development and Validation of a Comprehensive Instrument to Assess Unmet Spiritual Needs Rashmi K.

Armodafinil for Sarcoidosis-Associated Fatigue: A Double-Blind, Placebo-Controlled, Crossover Trial Elyse E. Lower, MD, Atul Malhotra, MD, Victoria Surdulescu,

Calibration of Quality-Adjusted Life Years for Oncology Clinical Trials Jeff A. Sloan, PhD, Daniel J. Sargent, PhD, Paul J. Novotny, MS, Paul A. Decker,

Randomized, Double-Blind, Placebo-Controlled Trial of Oral Docusate in the Management of Constipation in Hospice Patients Yoko Tarumi, MD, Mitchell P.

Is the B12/CRP Index More Accurate Than You at Predicting Life Expectancy in Advanced Cancer Patients? Filipa Tavares, MD Journal of Pain and Symptom.

Development and Reliability Testing of the Victoria Bowel Performance Scale (BPS) G. Michael Downing, MD, Craig Kuziemsky, PhD, Mary Lesperance, PhD,

Association Between Symptom Distress and Survival in Outpatients Seen in a Palliative Care Cancer Center J. Lynn Palmer, PhD, Michael J. Fisch, MD, MPH

A New Approach to Eliciting Patients' Preferences for Palliative Day Care: The Choice Experiment Method Hannah-Rose Douglas, PhD, Charles E. Normand,

Margot E. Kurtz, PhD, Jay C. Kurtz, PhD, Charles W

Comparative Efficacy of Oral Extended-Release Hydromorphone and Immediate- Release Hydromorphone in Patients with Persistent Moderate to Severe Pain: Two.

A Double-Blind, Randomized, Crossover Comparison Between Single-Dose and Double-Dose Immediate-Release Oral Morphine at Bedtime in Cancer Patients Ola.

Gabapentin and an Opioid Combination Versus Opioid Alone for the Management of Neuropathic Cancer Pain: A Randomized Open Trial Kader Keskinbora, MD,

Perceived Success in Addressing End-of-Life Care Needs of Low-Income Elders and Their Families: What Has Family Conflict Got to Do With It? Betty J.

A Meta-Analysis of the Relationship Between Response Expectancies and Cancer Treatment-Related Side Effects Stephanie J. Sohl, PhD, Julie B. Schnur,

Coping Strategies in the Presence of One's Own Impending Death from Cancer Lisa Sand, MSW, PhD (C), Mariann Olsson, MSW, PhD, Peter Strang, MD, PhD Journal.

Efficacy of Darbepoetin Alfa in Alleviating Fatigue and the Effect of Fatigue on Quality of Life in Anemic Patients with Lymphoproliferative Malignancies

Effects of Prophylactic Subcutaneous Fentanyl on Exercise-Induced Breakthrough Dyspnea in Cancer Patients: A Preliminary Double-Blind, Randomized, Controlled.

Using the Symptom Monitor in a Randomized Controlled Trial: The Effect on Symptom Prevalence and Severity Johanna Hoekstra, MA, Rien de Vos, PhD, Nico.

Giving Meaning to Measure: Linking Self-Reported Fatigue and Function to Performance of Everyday Activities Trudy Mallinson, PhD, David Cella, PhD, John.

Management of Phantom Pain with a Textile, Electromagnetically-Acting Stump Liner: A Randomized, Double-Blind, Crossover Study Uwe Kern, MD, Bernd Altkemper,

Optimizing Decision Making and Resource Allocation in Palliative Care

Cancer Symptom Clusters: A Validation Study

Associations Between Physical Activity and Quality of Life in Cancer Patients Receiving Palliative Care: A Pilot Survey Sonya S. Lowe, MD, MSc, Sharon.

Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment Gillian Prue, PhD, James Allen, PhD, Jacqueline Gracey, PhD, Jane Rankin,

Randomized Double-Blind Trial of Sublingual Atropine vs

Physical Activity Behaviors in Individuals with Multiple Sclerosis: Roles of Overall and Specific Symptoms, and Self-Efficacy Erin M. Snook, MS, Robert.

Presentation transcript:

Effects of Methylphenidate on Fatigue and Depression: A Randomized, Double-Blind, Placebo-Controlled Trial Christopher W. Kerr, MD, PhD, Julie Drake, PharmD, Robert A. Milch, MD, FACS, Daniel A. Brazeau, PhD, Judith A. Skretny, MA, Gayle A. Brazeau, PhD, James P. Donnelly, PhD Journal of Pain and Symptom Management Volume 43, Issue 1, Pages 68-77 (January 2012) DOI: 10.1016/j.jpainsymman.2011.03.026 Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Flow diagram of study phases. Journal of Pain and Symptom Management 2012 43, 68-77DOI: (10.1016/j.jpainsymman.2011.03.026) Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 Comparison of mean fatigue scores for placebo- and MP-treated groups according to three indices of fatigue. Results reported as mean fatigue scores at baseline (Day 0), Days 3, 7, and 14. Key: a=significantly different between Days 0 and 14 with P<0.05; b=significantly different between placebo and control with P<0.05. Journal of Pain and Symptom Management 2012 43, 68-77DOI: (10.1016/j.jpainsymman.2011.03.026) Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 Comparison of Piper Fatigue subscale scores for placebo- and MP-treated groups. Results reported as percent change from baseline at Days 3, 7, and 14. Key: a=significantly different between Days 0 and 14 with P<0.05; b=significantly different between placebo and control with P<0.05. Journal of Pain and Symptom Management 2012 43, 68-77DOI: (10.1016/j.jpainsymman.2011.03.026) Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 Comparison of mean scores for placebo- and MP-treated groups according to three indices of depression. Results reported are mean average depression scores at baseline (Day 0), Days 3, 7, and 14. Key: a=significantly different between Days 0 and 14 with P<0.05; b=significantly different between placebo and control with P<0.05. Journal of Pain and Symptom Management 2012 43, 68-77DOI: (10.1016/j.jpainsymman.2011.03.026) Copyright © 2012 U.S. Cancer Pain Relief Committee Terms and Conditions