Baseline Left Ventricular Volume and Shape as Determinants of Reverse Remodeling Induced by Surgical Ventricular Reconstruction Marisa Di Donato, MD,

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Baseline Left Ventricular Volume and Shape as Determinants of Reverse Remodeling Induced by Surgical Ventricular Reconstruction Marisa Di Donato, MD, Serenella Castelvecchio, MD, Daniel Burkhoff, MD, PhD, Alessandro Frigiola, MD, Abdallah Raweh, MD, Lorenzo Menicanti, MD The Annals of Thoracic Surgery Volume 92, Issue 5, Pages 1565-1571 (November 2011) DOI: 10.1016/j.athoracsur.2011.04.062 Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flow chart shows the selection of the study patients treated by surgical ventricular reconstruction (SVR) and the excluded cohort. The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Left ventricular volume changes after surgical ventricular reconstruction (SVR) at three intervals in patients with (squares) and without (diamonds) reverse remodeling. Median values are reported. (EDVI = end-diastolic volume index; EF = ejection fraction; ESVI = end-systolic volume index; FUP = follow-up; SVI = stroke volume index.) **p = 0.05. ***p = 0.01. The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Preoperative (Pre) and follow-up (FUP) single end-systolic volume index (ESVI) values are shown for patients with (A) no reverse remodeling and with (B) reverse remodeling after surgical ventricular reconstruction. Note the wide standard deviation (SD). The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Time course changes in end-systolic volume index (ESVI) according to four categories representing different times postoperatively to echocardiography at follow-up. No differences among categories were significant. The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Receiver operating characteristic curves were calculated for (A) end-systolic volume index (mL/m2), (B) conicity index, and (C) apical axis (cm) in systole to predict no reverse remodeling. The area under the curve (AUC) and confidence intervals (CI) are shown for each variable. The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Shape and size abnormalities were combined in a receiver operating characteristic curve analysis to predict no-reverse remodeling. (AUC = area under the curve; CI = confidence interval.) The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 Kaplan-Meier analysis shows follow-up (FUP) cumulative (cum) survival in patients with (blue line) and without (green line) reverse remodeling (RR). No significant difference was found between the two groups. The Annals of Thoracic Surgery 2011 92, 1565-1571DOI: (10.1016/j.athoracsur.2011.04.062) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions