Donna M. Martin, Yehoash Raphael Molecular Therapy

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It’s All in the Delivery: Improving AAV Transfection Efficiency with Exosomes Donna M. Martin, Yehoash Raphael Molecular Therapy Volume 25, Issue 2, Pages 309-311 (February 2017) DOI: 10.1016/j.ymthe.2017.01.004 Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions

Figure 1 Schematic Legend The outer ear canal (A) ends medially in the tympanic membrane (ear drum, B), connecting to the middle ear ossicles (C). The inner ear consists of the vestibular portion (D) and the cochlea (E). A cross-sectional view of the cochlear spiral is shown in higher magnification in the middle portion of the schematic, and the sensory region, the organ of Corti, is shown on the right. Inner hair cells (F) and outer hair cells (G) are transduced by the exo-AAV vector with high efficiency (brown), although some remain without transgene expression (magenta). Some supporting cells are also GFP positive (H, green). Molecular Therapy 2017 25, 309-311DOI: (10.1016/j.ymthe.2017.01.004) Copyright © 2017 The American Society of Gene and Cell Therapy Terms and Conditions