PLD and PA Take MT1-MMP for a Metastatic Ride

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Presentation transcript:

PLD and PA Take MT1-MMP for a Metastatic Ride Narendra Thapa, Richard A. Anderson Developmental Cell Volume 43, Issue 2, Pages 117-119 (October 2017) DOI: 10.1016/j.devcel.2017.10.012 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Lipid Signals Guide Assembly of Vesicle Trafficking Machinery to Drive MT1-MMP Targeting to Invadopodia Spatial generation of lipid signaling molecules, such as phosphatidic acid and phosphatidylinositio-4,5-bisphosphate, by lipid kinases such as PLD2 and PIP5K, respectively, at endosomal surfaces guide recruitment of different kinesin motors, exocyst complex and scaffolding protein IQGAP1. These complexes promote the trafficking and targeting of MT1-MMP-containing endosomes along microtubules for secretion at invadopodia. PC, phosphatidylcholine; PI4P, phosphatidylinositol-4 phosphate Developmental Cell 2017 43, 117-119DOI: (10.1016/j.devcel.2017.10.012) Copyright © 2017 Elsevier Inc. Terms and Conditions