Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management – meta-analyses  Daniele Santi, Giorgia.

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Presentation transcript:

Sperm DNA fragmentation index as a promising predictive tool for male infertility diagnosis and treatment management – meta-analyses  Daniele Santi, Giorgia Spaggiari, Manuela Simoni  Reproductive BioMedicine Online  Volume 37, Issue 3, Pages 315-326 (September 2018) DOI: 10.1016/j.rbmo.2018.06.023 Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Study flow chart showing the search results for the studies included in Meta-analysis 1 comparing sperm DNA fragmentation index (sDF) in fertile and infertile men (Search 1) and in Meta-analysis 2 comparing sDF in infertile men before and after FSH administration (Search 2). Reproductive BioMedicine Online 2018 37, 315-326DOI: (10.1016/j.rbmo.2018.06.023) Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Forest plot comparing sDF in fertile with infertile men (Meta-analysis 1). Reproductive BioMedicine Online 2018 37, 315-326DOI: (10.1016/j.rbmo.2018.06.023) Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Receiver operator characteristics (ROC) curve for the identification of the best sDF threshold for the male infertility diagnosis. Area under the curve = 0.844, P < 0.001. Reproductive BioMedicine Online 2018 37, 315-326DOI: (10.1016/j.rbmo.2018.06.023) Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Forest plot comparing sDF in infertile men before and after FSH administration (Meta-analysis 2). Reproductive BioMedicine Online 2018 37, 315-326DOI: (10.1016/j.rbmo.2018.06.023) Copyright © 2018 Reproductive Healthcare Ltd. Terms and Conditions

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