Age- and therapy-related effects on morphine requirements and plasma concentrations of morphine and its metabolites in postoperative infants N.J. Bouwmeester,

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Age- and therapy-related effects on morphine requirements and plasma concentrations of morphine and its metabolites in postoperative infants N.J. Bouwmeester, J.N. van den Anker, W.C.J. Hop, K.J.S. Anand, D Tibboel British Journal of Anaesthesia Volume 90, Issue 5, Pages 642-652 (May 2003) DOI: 10.1093/bja/aeg121 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 Percentages of patients in the four age groups (I 0–4 weeks, II ≥4–26 weeks, III ≥26–52 weeks, IV ≥1–3 yr) needing additional morphine during the first 24 h after surgery. British Journal of Anaesthesia 2003 90, 642-652DOI: (10.1093/bja/aeg121) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) Morphine, (b) morphine-3-glucuronide (M3G) and (c) morphine-6-glucuronide (M6G) plasma concentrations (median) in the four age groups (I 0–4 weeks, II ≥4–26 weeks, III ≥26–52 weeks, IV ≥1–3 yr) at 6, 12 and 24 h after surgery. CM=continuous morphine, IM=intermittent morphine. British Journal of Anaesthesia 2003 90, 642-652DOI: (10.1093/bja/aeg121) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions