Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Inflammatory APC show highest expression of TNF superfamily.

Slides:

Advertisements

Similar presentations

Volume 27, Issue 4, Pages (October 2007)

Advertisements

Volume 40, Issue 6, Pages (June 2014)

Depletion of CD169+ cells leads to increased expression of CD25 on enterotoxin A–specific Vβ3+ T cells. Depletion of CD169+ cells leads to increased expression.

IRF4 is required for anabolic induction of CD4+ T cells.

Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand Junyan Han, PhD, Azzeddine.

B-cell differentiation associates with down-regulation of vimentin expression. B-cell differentiation associates with down-regulation of vimentin expression.

Human dendritic cell subset 4 (DC4) correlates to a subset of CD14dim/−CD16++ monocytes Federica Calzetti, BS, Nicola Tamassia, PhD, Alessandra Micheletti,

Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Variable levels of cell surface and intracellular marker expression by HuT78 and HuT102 cells. Variable levels of cell surface and intracellular marker.

Increased chemokine content and leukocyte infiltrate in D6-negative tumors. Increased chemokine content and leukocyte infiltrate in D6-negative tumors.

Volume 22, Issue 13, Pages (March 2018)

VLPs activate DCs and antigen-specific CD8+ T cells via the STING and cGAS pathway. VLPs activate DCs and antigen-specific CD8+ T cells via the STING and.

CD160−/− IELs have a defect in granzyme B production during L

Human mast cells drive memory CD4+ T cells toward an inflammatory IL-22+ phenotype Nicolas Gaudenzio, PhD, Camille Laurent, MD, Salvatore Valitutti,

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Altered cytokine production by Klrk1−/− NOD CTL

Specific depletion of CD4-DTR–derived CD4 T cells.

STAT3 regulates IgE class switching in a Th2-type response.

CD160−/− mice have impaired clearance of oral L

Volume 17, Issue 3, Pages (October 2016)

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

LV activation of DCs and subsequent CD8+ T cell priming are dependent on STING and cGAS but not on MyD88, TRIF, or MAVS. LV activation of DCs and subsequent.

IL-33 treatment improves restorative macrophages (MΦ) but not function

IFN-γ induces TNF family ligand protein expression in vitro and in vivo. IFN-γ induces TNF family ligand protein expression in vitro and in vivo. (A and.

Elicited and steady-state transport of skin self-antigens in PYNOD-KO mice. Elicited and steady-state transport of skin self-antigens in PYNOD-KO mice.

TNFα-producing CD3+CD4+CD44+ infiltrating cells.

Volume 13, Issue 6, Pages (November 2015)

Fig. 2. IL-2/rapamycin–expanded T cells express homing receptors to traffic to lymphoma sites and are resistant to SN-38 toxicity. IL-2/rapamycin–expanded.

Volume 35, Issue 4, Pages (October 2011)

Resistance of CD141+ DCs to influenza virus in vivo in humanized mice.

IL-2c treatment preferentially expands injurious Tbet+ Tregs and inflammatory macrophages (MΦ) in skeletal muscle during chronic T. gondii infection. IL-2c.

Volume 47, Issue 5, Pages e9 (November 2017)

PD-1–PD-L1 axis is highly expressed and is not IFNγ-dependent in a subcutaneous murine model of PDA. A, experimental design for establishment of subcutaneous.

Volume 15, Issue 11, Pages (June 2016)

High-dimensional analysis of effector CD4 T cell function following γHV68 infection in B6 and IL-10KO mice. High-dimensional analysis of effector CD4 T.

Ag 85A–specific immune responses.

Tfr cells robustly secrete IL-10 after acute viral infection.

Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. Tfr cell–derived IL-10 is important for B cell differentiation and.

Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.

Volume 40, Issue 2, Pages (February 2014)

High-dimensional analysis of IL-10–dependent regulation of the antiviral response in the lung and the colon. High-dimensional analysis of IL-10–dependent.

Persistent TCR–pMHC-I signaling drives the formation and maintenance of exhausted-like TRM cells. Persistent TCR–pMHC-I signaling drives the formation.

TCR signaling is required for exhausted-like TRM cell formation and maintenance. TCR signaling is required for exhausted-like TRM cell formation and maintenance.

The mucosal environment regulates CD160 expression on IELs

The microbiota downregulate CD160 expression on IELs

PD-L1 selectively marks circulating NCMs.

CD27 expression on bovine γδ and CD4 T cells ex vivo and in response to mitogen. CD27 expression on bovine γδ and CD4 T cells ex vivo and in response to.

AhR activation reduces lung DC gene and surface expression of DC-SIGN.

CD8α+, CD8α−, and MoDCs from NOD.hCD205 mice express hCD205.

RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development. RAPTOR deficiency impairs the DN-to-DP transition in αβ T cell development.

Supplementation of c-Rel–competent Treg cells reverts exacerbated diabetes in c-Rel−/− NOD mice. Supplementation of c-Rel–competent Treg cells reverts.

Members of IL-1 family of cytokines favor the generation of IL-3–secreting CD4+ T cells in vitro. Members of IL-1 family of cytokines favor the generation.

Dynamic regulation of cell metabolism and mTORC1 activity and the requirement of RAPTOR in thymocyte development. Dynamic regulation of cell metabolism.

IL-27 induces expression of multiple IR by CD8+ T cells.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

Vaginal CD11c+ DCs from IL-17A−/− mice are impaired in potentiating Th17 responses because of diminished IL-1β production. Vaginal CD11c+ DCs from IL-17A−/−

Human Tfr cells do not express CD25.

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

CD25 expression predicts effector and memory differentiation.

Mice with a B cell–specific loss of Ets1 have reduced marginal zone B cells and increased ASCs. (A) Flow cytometry analysis of CD21 versus CD23 in gated.

Local proliferation of infiltrating circulating memory T cells.

IL35 regulation of tumor growth is accompanied by suppression of CD4+ effector T-cell activity and expansion of Tregs. IL35 regulation of tumor growth.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

Fig. 5 IL-5–mediated signaling is critical for the development of CD1dintCD5+ Breg precursor cells and IL-10+ Breg cells. IL-5–mediated signaling is critical.

Acute circadian disruption alters ILC3 cytokine secretion.

E2 induces IL-17–producing γδ+ T cells in the FGT

Surface expression of chemokine receptors on M

IL-17 produced by innate sources in the FGT is critical for potentiating Th17 responses primed by vaginal APCs. Vaginal cells from hormone cycle–matched.

Presentation transcript:

Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Lung APC subsets from (A) day (D) 3 p.i. and (B) D8 p.i. with LCMV 13 were analyzed for TNF superfamily ligand expression by flow cytometry using the gating strategy described in Supplemental Fig. 2. Left, Summary plots. Right, Representative histograms color coded to match the summary plots at left. Data represent mean ± SEM with six mice pooled from two independent experiments. Two-tailed, nonparametric unpaired t test was used for statistical analysis for all experiments. dMFI refers to the MFI for the specific Ab stain minus the FMO control. *p < 0.05, **p < 0.01. ns, not significant. Kuan C. Wang et al. ImmunoHorizons 2018;2:407-417 Copyright © 2018 The Authors