Hendrik T. Tevaearai, MD, G. Brant Walton, BS, Andrea D

Slides:

Advertisements

Similar presentations

The coronary delivery of marrow stromal cells for myocardial regeneration: Pathophysiologic and therapeutic implications Jih-Shiuan Wang, MD, Dominique.

Advertisements

Max B. Mitchell, MD The Journal of Thoracic and Cardiovascular Surgery

Manuel J. Antunes, MD, PhD, DSc

Myocardial protection with oxygenated esmolol cardioplegia during prolonged normothermic ischemia in the rat Ryuzo Bessho, MD, PhD, David J. Chambers,

Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury Sivakkanan Loganathan, Tamás Radovits, MD, PhD, Kristóf Hirschberg,

Translocation of a single coronary artery from the nonfacing sinus in the arterial switch operation: Long-term patency of the interposition graft Igor.

An unusual case of severe aortic valve stenosis in an adult caused by aortic valve inflammatory myofibroblastic tumor Dong Zhao, MD, Chunsheng Wang,

Multigene adenoviral therapy for the attenuation of ischemia-reperfusion injury after preservation for cardiac transplantation Haitham J. Abunasra, FRCS,

The use of technetium tc 99m annexin V for in vivo imaging of apoptosis during cardiac allograft rejection Patrick W. Vriens, MDa, Francis G. Blankenberg,

Novel mechanism of mitral regurgitation after lung transplantation in a patient with scleroderma and pulmonary hypertension Christian A. Bermudez, MD,

Ventricular and pulmonary vascular remodeling induced by pulmonary overflow in a chronic model of pretricuspid shunt Daniele Linardi, MD, Alessio Rungatscher,

Renal vein injury complicating removal of intravenous leiomyoma

Dynamic cardiac compression improves contractile efficiency of the heart Osamu Kawaguchi, MDa, Yoichi Goto, MDb, Yuichi Ohgoshi, MDb, Hitoshi Yaku, MDb,

Linear end-systolic pressure-volume relationship during pulsatile left ventricular bypass represents native heart function Osamu Kawaguchi, MD, John.

Working heart model of heterotopic heart-lung transplantation in rats

Stem cell therapy in the aging hearts of Fisher 344 rats: Synergistic effects on myogenesis and angiogenesis Jiang-Yong Min, MD, Yu Chen, MD, Sohail.

Thrombosis of the pulmonary artery stump after distal ligation

Orientation of bileaflet mechanical aortic valve prostheses for optimal evaluation by transthoracic echocardiography Alberto Bouzas-Mosquera, MD, PhD,

Biodegradable vs Nonbiodegradable Cardiac Support Device for Treating Ischemic Cardiomyopathy in a Canine Heart Mutsunori Kitahara, MD, Shigeru Miyagawa,

Persistence of marrow stromal cells implanted into acutely infarcted myocardium: Observations in a xenotransplant model Derek J. MacDonald, MD, Jun Luo,

Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension Edward P Chen, MD, Shahab A Akhter, MD, Hartmuth.

Walter J. Scott, M.D., Bruce L. Gewertz, M.D.

Tomohiro Mizuno, MD, Richard D. Weisel, MD, Ren-Ke Li, MD, PhD

Veno-venous bypass to prevent myocardial ischemia during right heart bypass operation in PA, IVS, and RV dependent coronary circulation Toshihide Asou,

Targeted overexpression of leukemia inhibitory factor to preserve myocardium in a rat model of postinfarction heart failure Mark F. Berry, MD, Timothy.

Centers for Disease Control “increased-risk” organ donor: Not so risky? Francis D. Pagani, MD, PhD The Journal of Thoracic and Cardiovascular Surgery

Levosimendan is superior to epinephrine in improving myocardial function after cardiopulmonary bypass with deep hypothermic circulatory arrest in rats

Management of a Stenotic Right Ventricle-Pulmonary Artery Shunt Early After the Norwood Procedure Tain-Yen Hsia, MD, Francesco Migliavacca, PhD, Giancarlo.

Alternation of left ventricular load by a continuous-flow left ventricular assist device with a native heart load control system in a chronic heart failure.

Form ever follows function

Left ventricular unloading before reperfusion reduces endothelin-1 release and calcium overload in porcine myocardial infarction Sophie Tamareille, PhD,

Autosynchronized systolic unloading during left ventricular assist with a centrifugal pump Satoshi Kono, MDa, Kazunobu Nishimura, MD, PhDa, Takeshi Nishina,

Aortic valve graft implantation in rats: a new functional model

Osamu Kawaguchi, MD, Walter E. Pae, MD, FACS, Bill B

Heart and en-bloc thymus transplantation in miniature swine

Evaluation of right ventricular function after cardiac surgery: The importance of tricuspid annular plane systolic excursion and right ventricular ejection.

Acute left ventricular failure after bilateral lung transplantation for idiopathic pulmonary arterial hypertension Tom Verbelen, MD, Sophie Van Cromphaut,

Improved heart function with myogenesis and angiogenesis after autologous porcine bone marrow stromal cell transplantation Shinji Tomita, MD, PhD, Donald.

Maher N. Abadeer, MD, Peter C. Kouretas, MD, PhD, Ronald K

Use of a bovine jugular vein graft with natural valve for right ventricular outflow tract reconstruction: A one-year animal study Yukio Ichikawa, MD,

Total body retrograde perfusion during operations on the descending thoracic aorta Kenzo Yasuura, MD, Yasushi Takagi, MD, Yasutoshi Oohara, MD, Yoshiyuki.

Transplantation of cryopreserved cardiomyocytes

A first start for lung transplantation?

Early effects of right ventricular volume overload on ventricular performance and β- adrenergic signaling Ashish S. Shah, MD, B.Zane Atkins, MD, Jonathan.

Significant improvement of heart function by cotransplantation of human mesenchymal stem cells and fetal cardiomyocytes in postinfarcted pigs Jiang-Yong.

Organ perfusion with hemopump device assistance with and without intraaortic balloon pumping Bart Meyns, MD, Yousuke Nishimura, MD, Rozalia Racz, MD,

Giant metastatic myxoid liposarcoma of the mediastinum: A case report

Mechanisms of tolerance induction and prevention of cardiac allograft vasculopathy in miniature swine: The effect of augmentation of donor antigen load

Extracellular and standard University of Wisconsin solutions provide equivalent preservation of myocardial function Davis C. Drinkwater, MDa, Eli T.

Restoration of left ventricular geometry and improvement of left ventricular function in a rodent model of chronic ischemic cardiomyopathy Jiashing Yu,

Aortic Translocation for the Management of Double-Outlet Right Ventricle and Pulmonary Stenosis With Dextrocardia: Technique to Avoid Coronary Insufficiency

Prevascularization with gelatin microspheres containing basic fibroblast growth factor enhances the benefits of cardiomyocyte transplantation Yutaka.

Gregory A Thomas, MD, Larry W Stephenson, MD

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Chronic septal infarction confers right ventricular protection during mechanical left ventricular unloading James Mau, BSc, MB, BS, Stuart Menzie, MB,

Correlation between ICAM-1 and functional recovery of piglet myocardium with leukocyte-depleted reperfusion Jeong Ryul Lee, MD, Jae Jin Han, MD, Jeong.

Functional analysis of cryopreserved veins

Ralph S. Mosca, MD The Journal of Thoracic and Cardiovascular Surgery

Analysis of right ventricular function during bypass of the left side of the heart by afterload alterations in both normal and failing hearts Chang-Hee.

Preserving the V-engine shape of the left ventricle with Melody mitral valve replacement in small children Patrick O. Myers, MD The Journal of Thoracic.

Hypoplastic Left Heart Syndrome With Anomalous Origin of the Right Coronary Artery Julie Cleuziou, MD, Felix Haas, MD, Christian Schreiber, MD, Hans-Jörg.

Tai Ji: The law of inflammatory response

Neo-Left Atrium Construction on the Beating Heart After Extirpation of a Huge Mediastinal Tumor Invading Heart and Lung Miralem Pasic, MD, PhD, Evgenij.

Homograft valve repair for recurrent prosthetic valve endocarditis

Effects of acute left ventricular unloading on right ventricular function in normal and chronic right ventricular pressure-overloaded lambs Boudewijn.

Unintended right-to-left shunt after Fontan operation: Consequence of unligated vertical vein in a child with total anomalous pulmonary venous drainage,

Mechanical left ventricular unloading to prevent recurrent myocardial rupture Stephen Westaby, MS, PhD, Vipin Mehta, MD, Fidelma Flynn, MD, Neil Wilson,

Hemodynamics and aneurysm development in vascular allografts

Aneurysmal right coronary with fistula to the coronary sinus combined with severe stenosis of the left anterior descending artery: A snake on the heart

Right ventricle-sparing heart transplant: promising new technique for recipients with pulmonary hypertension John A Elefteriades, MD, Costantinos J Lovoulos,

Presentation transcript:

Heterotopic transplantation as a model to study functional recovery of unloaded failing hearts Hendrik T. Tevaearai, MD, G.Brant Walton, BS, Andrea D. Eckhart, PhD, Janelle R. Keys, PhD, Walter J. Koch, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 6, Pages 1149-1156 (December 2002) DOI: 10.1067/mtc.2002.127315 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Schematic representation of blood circulation within heterotopically transplanted heart. Oxygenated blood originating from one recipient artery (carotid artery [CA] in our case) retroperfuses donor aorta (Ao) and irrigates coronary arteries of transplanted heart while aortic valve prevents regurgitation into LV. Coronary sinus drains myocardial blood into right cavities, whence it is ejected toward donor pulmonary artery (PA) and recipient vein (jugular vein [JV] in our case). RA, Right atrium; RV, right ventricle. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1149-1156DOI: (10.1067/mtc.2002.127315) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Comparison of representative histologic slices obtained from native heart of recipient rabbit (A and C) and from heterotopically transplanted heart 30 days after transplantation (B and D). Slight infiltration with polymorphonuclear cells (B, hematoxylin and eosin) and zones of fibrosis (D, trichrome-Masson stain) can be seen in heterotopically transplanted heart as compared with native heart (A, hematoxylin and eosin; C, trichrome-Masson stain), accounting for moderate chronic rejection. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1149-1156DOI: (10.1067/mtc.2002.127315) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 LV contractility (LV dP/dtmax, A and B) and relaxation (LV dP/dtmin, C and D) in failing hearts unloaded for 30 days (n = 5). Values were obtained every 5 days, with (B and D) or without (A and C) stimulation with isoproterenol (ISO) at 0.1 μg/(kg · min) under two preload conditions: LVEDV of basal plus 0.1 mL (open squares and filled squares) and LVEDV of basal plus 0.3 mL (open triangles and filled triangles). Results are expressed as percentage of basal value obtained at day 1 with preload of 0 mL and without isoproterenol stimulation. Asterisk indicates P <.05 by 1-way analysis of variance for repeated measures; dagger indicates P <.05 for preload of basal plus 0.1 mL; double dagger indicates P <.001 for preload of basal plus 0.3 mL. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1149-1156DOI: (10.1067/mtc.2002.127315) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Progression of LV pressure/volume relationship in unloaded failing hearts (4 weeks after coronary ligation, n = 5). LVEDP responses to increased preload are shown for day 1 (open squares), day 5 (filled triangles), day 15 (open triangles), and day 30 (filled squares). Asterisk indicates P <.05 versus day 1. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1149-1156DOI: (10.1067/mtc.2002.127315) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Comparison of 20-day period of unloading on ventricular function in failing hearts 3 weeks after coronary ligation (n = 5, A and C) versus 3 months after coronary ligation (n = 3, B and D). LV contractility (LV dP/dtmax, A and B) and relaxation (LV dP/dtmin, C and D) are shown for different hemodynamic conditions. Asterisk indicates P <.05 for basal versus mechanical stimulation; dagger indicates P <.05 for basal versus isoproterenol (ISO) stimulation; double dagger indicates P <.001 for basal versus mechanical and isoproterenol stimulation. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1149-1156DOI: (10.1067/mtc.2002.127315) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 Comparison of LV systolic pressures in response to mechanical stimulation measured on day 1 (open squares and open triangles) and day 20 (filled squares and filled triangles) after heterotopic heterotopic transplantation and ventricular unloading of failing hearts. Hearts were transplanted 3 weeks (open squares and filled squares, n = 5) or 3 months (open triangles and filled triangles) after coronary ligation. Asterisk indicates P =.01 for added preload of 0.3 mL versus basal; dagger indicates P <.005 for day 20 versus day 1. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1149-1156DOI: (10.1067/mtc.2002.127315) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions