Optimal Treatment of PAH

Endothelial Dysfunction in PAH

Treatment Algorithm for PAH

Recommendations for General Measures

Recommendations for Supportive Therapy

Treatment Algorithm for PAH

Risk Assessment in PAH

Treatment Algorithm for PAH

Monotherapy Recommendations for PAH

Initial Combination Therapy Recommendations for PAH

Sequential Combination Therapy Recommendations for PAH

The Rationale for Combination Therapy

Expert Consensus Recommendations for Combination Therapy Have Improved With Increasing Experience

An Evolving Paradigm From Sequential to Initial Upfront Combination Therapy

AMBITION Study Design

AMBITION Results

Initial Dual Oral Combination Therapy for PAH Experience of the French Network

Initial Dual Oral Combination Therapy for PAH Experience of the French Network

Selexipag

GRIPHON Selexipag for the Treatment of PAH

GRIPHON Primary End Point

Looking Forward

Abbreviations

Abbreviations (cont)

Abbreviations (cont)

References

References (cont)

References (cont)