The Stone Age Plague and Its Persistence in Eurasia Aida Andrades Valtueña, Alissa Mittnik, Felix M. Key, Wolfgang Haak, Raili Allmäe, Andrej Belinskij, Mantas Daubaras, Michal Feldman, Rimantas Jankauskas, Ivor Janković, Ken Massy, Mario Novak, Saskia Pfrengle, Sabine Reinhold, Mario Šlaus, Maria A. Spyrou, Anna Szécsényi-Nagy, Mari Tõrv, Svend Hansen, Kirsten I. Bos, Philipp W. Stockhammer, Alexander Herbig, Johannes Krause  Current Biology  Volume 27, Issue 23, Pages 3683-3691.e8 (December 2017) DOI: 10.1016/j.cub.2017.10.025 Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 1 Maximum-Likelihood Tree and Percent Coverage Plot of Virulence Factors of Yersinia pestis (A) Maximum-likelihood tree of all Yersinia pestis genomes, including 1,265 SNP positions with complete deletion. Nodes with support ≥ 95% are marked with an asterisk. The colors represent different branches in the Y. pestis phylogeny: branch 0 (black), branch 1 (red), branch 2 (green), branch 3 (blue), branch 4 (orange), and LNBA Y. pestis branch (purple). Y. pseudotuberculosis-specific SNPs were excluded from the tree for clarity of representation. In the light-colored boxes, discussed losses and gains of genomic regions and genes are indicated. Related to Figure S3. (B) Percent coverage of virulence factors located on the Yersinia pestis chromosome and plasmids, plotted in R using the ggplot2 package. The numbers represent specific genes: (1) ymt gene, (2) pla gene, (3) filamentous prophage YpfΦ, (4) Y. pestis-specific genes. Related to Figure S2. See also Data S1. Current Biology 2017 27, 3683-3691.e8DOI: (10.1016/j.cub.2017.10.025) Copyright © 2017 Elsevier Ltd Terms and Conditions

Figure 2 Map of Proposed Yersinia pestis Circulation throughout Eurasia (A) Entrance of Y. pestis into Europe from Central Eurasia with the expansion of Yamnaya pastoralists around 4,800 years ago. (B) Circulation of Y. pestis to Southern Siberia from Europe. Only complete genomes are shown. Current Biology 2017 27, 3683-3691.e8DOI: (10.1016/j.cub.2017.10.025) Copyright © 2017 Elsevier Ltd Terms and Conditions